American Journal of Tropical Medicine and Hygiene
| Autor: | Aquino, Dorlene Maria Cardoso de, Caldas, Arlene de Jesus Mendes, Miranda, José Carlos, Silva, Antonio A. M., Barral-Netto, Manoel, Barral, Aldina Maria Prado |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.4269/ajtmh.2010.10-0182 |
| Popis: | Texto completo: acesso restrito. p.825-827 Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-08-01T17:45:07Z No. of bitstreams: 1 Dorlene M. C. Aquino.pdf: 557538 bytes, checksum: 95382594fd4746a392752483557e5fdb (MD5) Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-08-05T12:35:42Z (GMT) No. of bitstreams: 1 Dorlene M. C. Aquino.pdf: 557538 bytes, checksum: 95382594fd4746a392752483557e5fdb (MD5) Made available in DSpace on 2013-08-05T12:35:42Z (GMT). No. of bitstreams: 1 Dorlene M. C. Aquino.pdf: 557538 bytes, checksum: 95382594fd4746a392752483557e5fdb (MD5) Previous issue date: 2010 Recent reports from animal models and from cross-sectional studies have suggested that host responses to anti-Lutzomyia longipalpis saliva antibodies may be related to delayed-type hypersensitivity to Leishmania antigen. In a prospective cohort study, we evaluated 1,080 children from two endemic areas for visceral leishmaniasis (VL) by means of Kaplan-Meier analysis. The incidence rate of delayed-type hypersensitivity to Leishmania antigen, measured at the 24th follow-up month, was higher among those reactive to Lu. longipalpis saliva antibodies at the beginning of the study (0.0217 cases per person-month) than among those previously negative (0.0131 cases per person-month) (P value for the log-rank test = 0.0006). It seems that mounting an anti-saliva immune response helps the development of a cell-mediated anti-Leishmania response. |
| Databáze: | OpenAIRE |
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