ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′ -BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES
| Autor: | Özbek,Hülya Avci, Çinar,Seda, Oskay,Mustafa, Aydemİr,Tülİn, Demİrhan,Funda |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of the Chilean Chemical Society v.66 n.3 2021 SciELO Chile CONICYT Chile instacron:CONICYT |
| Popis: | The synthesized N,N′ -bis(ferrocenylmethylene)ethylenediamine Schiff base and it’s metal complexes were screened in vitro for antimicrobial activity against two Gram-positive ( Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 7064), four Gram-negative ( Escherichia coli ATCC 25922, Citrobacter koseri DBCC 01, Entorebacter aeruginosa ATCC 13048, Salmonella typhimurium DBCC 02) and antifungal activity against a Candida albicans . MIC values of the compounds ranged from 27 to 533 μg/mL. Compound (5) showed very strong activity against S. aureus with the best MIC (27 μg/mL). The lowest MIC for C. albicans was obtained 107 μg/mL. The superoxide dismutase activity of Schiff base and it’s metal complexes has been measured and discussed. SOD-like activities of bis ferrocenyl Schiff base ligand metal complexes were investigated using NBT. While only the Cu (II) complex showed SOD-like (40 μm IC50) activity, the SOD-like activity value was not determined in the other complex and ligand. |
| Databáze: | OpenAIRE |
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