Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age
| Autor: | Fabião, J., Sassi, B., Pedrollo, Elis Forcellini, Gerchman, Fernando, Kramer, Caroline Kaercher, Leitão, Cristiane Bauermann, Pinto, Lana Catani Ferreira |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
| ISSN: | 4202-0182 |
| Popis: | We aimed to study the mechanism behind worse coronavirus disease-19 (COVID-19) outcomes in men and whether the differences between sexes regarding mortality as well as disease severity are influenced by sex hormones. To do so, we used age as a covariate in the meta-regression and subgroup analyses. This was a systematic search and meta-analysis of observational cohorts reporting COVID-19 outcomes. The PubMed (Medline) and Cochrane Library databases were searched. The primary outcome was COVID-19-associated mortality and the secondary outcome was COVID-19 severity. The study was registered at PROSPERO: 42020182924. For mortality, men had a relative risk of 1.36 (95%CI: 1.17 to 1.59; I² 63%, P for heterogeneity |
| Databáze: | OpenAIRE |
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