Arq Neuropsiquiatr
| Autor: | Muniz, André Luís Nunes, Rodrigues Junior, Waldyr, Santos, Silvane Maria Braga, Jesus, Amélia Maria Ribeiro de, Porto, Maria Aurélia da Fonseca, Castro, Néviton Matos de, Oliveira Filho, Jamary, Almeida, Juliana Passos, Carvalho, Otavio Augusto Moreno de, Carvalho Filho, Edgar Marcelino de |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1590/S0004-282X2006000200009 |
| Popis: | p.217-221 Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-05-16T14:51:45Z No. of bitstreams: 1 Muniz, André Luiz.pdf: 397193 bytes, checksum: 353ac9e70f674339c8cf516b0af766c8 (MD5) Made available in DSpace on 2012-05-16T14:51:45Z (GMT). No. of bitstreams: 1 Muniz, André Luiz.pdf: 397193 bytes, checksum: 353ac9e70f674339c8cf516b0af766c8 (MD5) Previous issue date: 2006-06 Objective: To identify clinical and immunological markers associated with HTLV-I associated myelopath y / tropical spastic paraparesis (HAM/TSP). Method: 237 HTLV-I infected individuals were clinically assessed. They were classified according to the Expanded Disability Status Scale (EDSS) and Osame’s Motor Disability Score (OMDS). Cytokine levels were determined in HTLV-I seropositive individuals. Results: 37 patients had HAM/TSP. There was a correlation between the degrees of disability assessed by both scales. There was also a correlation between the duration of HAM/TSP and the severity of disability assessed by either EDSS or OMDS. Higher levels of IFN-were detected in unstimulated peripheral blood mononuclear cells (PBMC) from HAM/TSP patients as compared with HTLV-I carriers. Conclusion: This study shows the validity of the neurological scales to classify the degree of neurological disability in HTLV-I carriers and suggests a pro g ressive behavior of HAM/TSP. This study also shows that IFN-in PBMC supernatants are markers of HAM/TSP. São Paulo |
| Databáze: | OpenAIRE |
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