Aumento da biodisponibilidade de Bromelina no intestino atrav??s de estereocomplexa????o de Alginato e amino??cidos

Autor: Ricardo, Philipi Cavalcante
Přispěvatelé: Felix, Pedro Henrique Campelo, Serudo, Ricardo Lima, Paulino, Bruno Nicolau, Silva, Eric Keven
Jazyk: portugalština
Rok vydání: 2020
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações da UFAM
Universidade Federal do Amazonas (UFAM)
instacron:UFAM
Popis: Submitted by Philipi Cavalcante Ricardo (pcr.engquim@gmail.com) on 2021-01-20T17:30:11Z No. of bitstreams: 4 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) DISSERTA????O_DE_MESTRADO_PHILIPI.pdf: 15631003 bytes, checksum: 5ca7f2c420ca75e709fba700aa67d557 (MD5) Ata de Defesa de Disserta????o - Philipi Cavalcante.pdf: 217228 bytes, checksum: b7b022831ee0aa3f0d2a4f88054e0c5f (MD5) cartaencaminhamento.pdf: 41331 bytes, checksum: 837ad7a07152a8931f1f0daff9dabf76 (MD5) Approved for entry into archive by PPGCEM Ci??ncia e Engenharia de Materiais (ppgcem@ufam.edu.br) on 2021-01-20T20:11:10Z (GMT) No. of bitstreams: 4 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) DISSERTA????O_DE_MESTRADO_PHILIPI.pdf: 15631003 bytes, checksum: 5ca7f2c420ca75e709fba700aa67d557 (MD5) Ata de Defesa de Disserta????o - Philipi Cavalcante.pdf: 217228 bytes, checksum: b7b022831ee0aa3f0d2a4f88054e0c5f (MD5) cartaencaminhamento.pdf: 41331 bytes, checksum: 837ad7a07152a8931f1f0daff9dabf76 (MD5) Rejected by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br), reason: Aus??ncia da ficha catalogr??fica, devidamente inserida no arquivo da disserta????o. on 2021-01-21T14:44:42Z (GMT) Submitted by Philipi Cavalcante Ricardo (pcr.engquim@gmail.com) on 2021-01-21T17:40:47Z No. of bitstreams: 5 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Ata de Defesa de Disserta????o - Philipi Cavalcante.pdf: 217228 bytes, checksum: b7b022831ee0aa3f0d2a4f88054e0c5f (MD5) cartaencaminhamento.pdf: 41331 bytes, checksum: 837ad7a07152a8931f1f0daff9dabf76 (MD5) DISSERTA????O_DE_MESTRADO_PHILIPI.pdf: 15650749 bytes, checksum: 2efa9d87f033ebbdbb78041d46f9c1c7 (MD5) Ficha Catalogr??fica.pdf: 1903 bytes, checksum: fd5280892a9c5cbc018364678b204a7a (MD5) Approved for entry into archive by PPGCEM Ci??ncia e Engenharia de Materiais (ppgcem@ufam.edu.br) on 2021-01-21T18:56:03Z (GMT) No. of bitstreams: 5 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Ata de Defesa de Disserta????o - Philipi Cavalcante.pdf: 217228 bytes, checksum: b7b022831ee0aa3f0d2a4f88054e0c5f (MD5) cartaencaminhamento.pdf: 41331 bytes, checksum: 837ad7a07152a8931f1f0daff9dabf76 (MD5) DISSERTA????O_DE_MESTRADO_PHILIPI.pdf: 15650749 bytes, checksum: 2efa9d87f033ebbdbb78041d46f9c1c7 (MD5) Ficha Catalogr??fica.pdf: 1903 bytes, checksum: fd5280892a9c5cbc018364678b204a7a (MD5) Rejected by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br), reason: A ficha catalogr??fica precisa de ajuste. No campo "sobrenome do autor" inserir apenas "Ricardo", desta forma a ficha apresentar?? "Ricardo, Philipi Cavalcante" e o cutter (C376a) ser?? corrigido. A ficha poder?? ser refeita em https://biblioteca.ufam.edu.br/elaboracao-de-ficha-catalografica.html onde consta um tutorial, caso precise. on 2021-01-21T19:53:19Z (GMT) Submitted by Philipi Cavalcante Ricardo (pcr.engquim@gmail.com) on 2021-01-21T21:30:18Z No. of bitstreams: 5 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Ata de Defesa de Disserta????o - Philipi Cavalcante.pdf: 217228 bytes, checksum: b7b022831ee0aa3f0d2a4f88054e0c5f (MD5) cartaencaminhamento.pdf: 41331 bytes, checksum: 837ad7a07152a8931f1f0daff9dabf76 (MD5) Ficha Catalogr??fica.pdf: 1910 bytes, checksum: 33954e2785df429467f03d323e8fd55c (MD5) DISSERTA????O_DE_MESTRADO_PHILIPI.pdf: 15650823 bytes, checksum: 56fc80aef4a2090da921b019d217fcbc (MD5) Approved for entry into archive by PPGCEM Ci??ncia e Engenharia de Materiais (ppgcem@ufam.edu.br) on 2021-01-21T22:06:30Z (GMT) No. of bitstreams: 5 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Ata de Defesa de Disserta????o - Philipi Cavalcante.pdf: 217228 bytes, checksum: b7b022831ee0aa3f0d2a4f88054e0c5f (MD5) cartaencaminhamento.pdf: 41331 bytes, checksum: 837ad7a07152a8931f1f0daff9dabf76 (MD5) Ficha Catalogr??fica.pdf: 1910 bytes, checksum: 33954e2785df429467f03d323e8fd55c (MD5) DISSERTA????O_DE_MESTRADO_PHILIPI.pdf: 15650823 bytes, checksum: 56fc80aef4a2090da921b019d217fcbc (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2021-01-22T14:41:04Z (GMT) No. of bitstreams: 5 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Ata de Defesa de Disserta????o - Philipi Cavalcante.pdf: 217228 bytes, checksum: b7b022831ee0aa3f0d2a4f88054e0c5f (MD5) cartaencaminhamento.pdf: 41331 bytes, checksum: 837ad7a07152a8931f1f0daff9dabf76 (MD5) Ficha Catalogr??fica.pdf: 1910 bytes, checksum: 33954e2785df429467f03d323e8fd55c (MD5) DISSERTA????O_DE_MESTRADO_PHILIPI.pdf: 15650823 bytes, checksum: 56fc80aef4a2090da921b019d217fcbc (MD5) Made available in DSpace on 2021-01-22T14:41:04Z (GMT). No. of bitstreams: 5 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Ata de Defesa de Disserta????o - Philipi Cavalcante.pdf: 217228 bytes, checksum: b7b022831ee0aa3f0d2a4f88054e0c5f (MD5) cartaencaminhamento.pdf: 41331 bytes, checksum: 837ad7a07152a8931f1f0daff9dabf76 (MD5) Ficha Catalogr??fica.pdf: 1910 bytes, checksum: 33954e2785df429467f03d323e8fd55c (MD5) DISSERTA????O_DE_MESTRADO_PHILIPI.pdf: 15650823 bytes, checksum: 56fc80aef4a2090da921b019d217fcbc (MD5) Previous issue date: 2020-10-28 CAPES - Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior Pineapple contains proteolytic enzymes with biological properties of commercial interest, known as bromelains. Bromelains have potential for use as an analgesic, as an anti-inflammatory and in cancer treatments. Despite the therapeutic effects, proteins such as bromelain undergo degradation when administered orally, being degraded in the gastric digestion phase due to low pH and the attack of digestive enzymes. Microencapsulation processes have demonstrated great potential in the protection of proteins and as controlled release systems. Thus, this work aimed to develop encapsulating systems using sodium alginate as carrier material and positively charged amino acids as stabilizing agents for the controlled release of bromelain in the intestine, using in vitro tests. The systems were produced using experimental planning of centroid simplex mixtures. The characterizations were performed by FTIR which demonstrated that the bromelain was encapsulated in all systems, by XRD where it was observed that the systems are presented as amorphous solids and, by SEM which demonstrated that the morphology of the formed systems follows a microparticle pattern rough. The application of statistical analysis demonstrated that the formed systems present behavior that can be evaluated by a quadratic model, with p
Databáze: OpenAIRE
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