Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid

Autor:	Marona, Hérida R. N. [UNESP], Lopes, Cristiani C. G. O. [UNESP], Cardoso, Simone G.
Přispěvatelé:	Universidade Estadual Paulista (Unesp), Universidade Federal de Sergipe (UFS)
Jazyk:	angličtina
Rok vydání:	2003
Předmět:	excipient analytic method tablet accuracy crystal violet Non-aqueous titration titrimetry weight quantitative assay Gatifloxacin perchloric acid drug formulation acetic acid Fluoroquinolone validation process Pharmaceutical analysis quinoline derived antiinfective agent drug determination
Zdroj:	Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP
Popis:	Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:20:55Z No. of bitstreams: 0 Made available in DSpace on 2014-05-27T11:20:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2003-10-01 An inexpensive, simple, precise and rapid method for the determination of fluoroquinolone gatifloxacin in tablets is described. The procedure is based on the use of volumetric dosage in a non-aqueous medium in glacial acetic acid with 0.1 M perchloric acid. The method validation yielded good results and included the precision, recovery and accuracy. It was also found that the excipients in the commercial tablet preparation did not interfere with the assay. Prog. Pos-Graduacao Cie. Farmaceut. FCF UNESP, Araraquara, SP Centro de Ciencias da Saude UFSM, Santa Maria, RS Prog. Pos-Graduacao Cie. Farmaceut. FCF UNESP, Araraquara, SP
Databáze:	OpenAIRE
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