Designing a food digestion system for lipids rich in medium-chain fatty acids (MCFAs)

Autor: Pereira, Ericsem, 1988, Meirelles, Antonio José de Almeida, 1958, Maximo, Guilherme José, 1982
Přispěvatelé: UNIVERSIDADE ESTADUAL DE CAMPINAS
Rok vydání: 2022
Předmět:
Zdroj: Repositório da Produção Científica e Intelectual da Unicamp
Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP
Popis: Fats and oils are important sources of calories and nutrients, which digestion's involves a series of complex events occurring in the compartments of the human gastro-intestinal (GI) tract. Their bioaccessibility depends on the fraction of free fatty acids (FFAs) released into the GI lumen. Thus, the aim of this study was to evaluate the release of FFAs along the different phases of the human GI digestion. A dynamic GI model was used to investigate the gastric, duodenal, jejunal and ileal portions of the digestion of medium-chain triglyceride (MCT) and coconut oil samples. Digestive parameters such as delivery of simulated fluids (23 and 54 mL/h for gastric and intestinal fluids, respectively) and gastric empty (90 min) rates were determined based on standardized conditions found in international consensus for in vitro digestion protocols. Endpoint samples were collected at each phase, as well as filtrate portions from the membranes coupled to the jejunum and ileum compartments. Gas chromatography analyses were applied to quantify and obtain FFA profiles. Results showed that higher concentrations of free medium-chain fatty acids (MCFAs), particularly caprylic and capric acids, were found in the gastric and intestinal digestion phases, when compared to free long-chain fatty acids (LCFAs). It is worth noting that MCFAs preferential absorption and metabolic route enables them to instantly provide energy to the human body when released as FFAs in the stomach. We also observed that caprylic and capric acids concentrations found in filtrated aliquots taken from jejunal and ileal compartments are representative of the bioaccessibility of these nutrients. However, it was also noticed that small concentrations of free lauric acid, coconut oil major component, were found in filtrated samples, which suggests low bioaccessibility o this nutrient. Although the dynamic digestion system provided good estimations of lipolysis rates in the human gastrointestinal tract, further studies need to be conducted to evaluate protocols' performances with different oil samples FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO (FAPESP) CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO (CNPQ) COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR (CAPES) Aberto
Databáze: OpenAIRE
Externí odkaz: