Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats

Autor: Gaiolla, Paula Schmidt Azevedo [UNESP], Polegato, Bertha Furlan [UNESP], Minicucci, Marcos Ferreira [UNESP], Pio, Stephan M. [UNESP], Silva, Igor A. [UNESP], Santos, Priscila P. [UNESP], Okoshi, Katashi [UNESP], Paiva, Sergio Alberto Rupp de [UNESP], Zornoff, Leonardo Antonio Mamede [UNESP]
Přispěvatelé: Universidade Estadual Paulista (Unesp)
Jazyk: angličtina
Rok vydání: 2012
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Zdroj: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Popis: Made available in DSpace on 2013-08-12T17:53:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-07-01 Made available in DSpace on 2013-09-30T18:17:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-07-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:33:21Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T13:33:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-07-01 Botucatu Medical School Background: The objective of this study was to determine the early echocardiographic predictors of elevated left ventricular end-diastolic pressure (LVEDP) after a long follow-up period in the infarcted rat model.Material/Methods: Five days and three months after surgery, sham and infarcted animals were subjected to transthoracic echocardiography. Regression analysis and receiver-operating characteristic (ROC) curve were performed for predicting increased LVEDP 3 months after MI.Results: Among all of the variables, assessed 5 days after myocardial infarction, infarct size (OR: 0.760; CI 95% 0.563-0.900; p=0.005), end-systolic area (ESA) (OR: 0.761; Cl 95% 0.564-0.900; p=0.008), fractional area change (FAC) (OR: 0.771; CI 95% 0.574-0.907; p=0.003), and posterior wall-shortening velocity (PWSV) (OR: 0.703; CI 95% 0.502-0.860; p=0.048) were predictors of increased LVEDP. The LVEDP was 3.6 +/- 1.8 mmHg in the control group and 9.4 +/- 7.8 mmHg among the infarcted animals (p=0.007). Considering the critical value of predictor variables in inducing cardiac dysfunction, the cut-off value was 35% for infarct size, 0.33 cm(2) for ESA, 40% for FAC, and 26 mm/s for PWSV.Conclusions: Infarct size, FAC, ESA, and PWSV, assessed five days after myocardial infarction, can be used to estimate an increased LVEDP three months following the coronary occlusion. UNESP, Botucatu Med Sch, Dept Internal Med, BR-18618970 Botucatu, SP, Brazil UNESP, Botucatu Med Sch, Dept Internal Med, BR-18618970 Botucatu, SP, Brazil
Databáze: OpenAIRE
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