Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives

Autor: Melo, Ailton de Souza, Monteiro, Larissa, Lima, Rute Maria Ferreira, Oliveira, Diêgo Madureira de, Cerqueira, Martins Dias de, El-Bachá, Ramon dos Santos
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Repositório Institucional da UFBA
Universidade Federal da Bahia (UFBA)
instacron:UFBA
DOI: 10.1155/2011/467180
Popis: Submitted by Ramon El-Bachá (ramon@ufba.br) on 2016-10-01T22:11:12Z No. of bitstreams: 1 Melo et al 2011.pdf: 2735529 bytes, checksum: af9db5c06681334d8a7a23b30ccaf010 (MD5) Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2016-10-07T12:41:31Z (GMT) No. of bitstreams: 1 Melo et al 2011.pdf: 2735529 bytes, checksum: af9db5c06681334d8a7a23b30ccaf010 (MD5) Made available in DSpace on 2016-10-07T12:41:31Z (GMT). No. of bitstreams: 1 Melo et al 2011.pdf: 2735529 bytes, checksum: af9db5c06681334d8a7a23b30ccaf010 (MD5) Previous issue date: 2011 CNPq/CAPES The incidence and prevalence of neurodegenerative diseases (ND) increase with life expectancy. This paper reviews the role of oxidative stress (OS) in ND and pharmacological attempts to fight against reactive oxygen species (ROS)-induced neurodegeneration. Several mechanisms involved in ROS generation in neurodegeneration have been proposed. Recent articles about molecular pathways involved in ROS generation were reviewed. The progress in the development of neuroprotective therapies has been hampered because it is difficult to define targets for treatment and determine what should be considered as neuroprotective. Therefore, the attention was focused on researches about pharmacological targets that could protect neurons against OS. Since it is necessary to look for genes as the ultimate controllers of all biological processes, this paper also tried to identify gerontogenes involved in OS and neurodegeneration. Since neurons depend on glial cells to survive, recent articles about the functioning of these cells in aging and ND were also reviewed. Finally, clinical trials testing potential neuroprotective agents were critically reviewed. Although several potential drugs have been screened in in vitro and in vivo models of ND, these results were not translated in benefit of patients, and disappointing results were obtained in the majority of clinical trials.
Databáze: OpenAIRE
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