Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects
| Autor: | Rodrigues, Onaldo G., de Araújo, Gilmar T., Rolim, Hercília M. L., Nascimento, Silene C., Coelho, Luana C. B. B. |
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| Jazyk: | portugalština |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | RECEN-Revista de Ciências Naturais e Exatas; v. 4, n. 1 (2002); 73-78 RECEN-Revista Ciências Exatas e Naturais; v. 4, n. 1 (2002); 73-78 Revista Ciências Exatas e Naturais Universidade Estadual do Centro-Oeste (UNICENTRO) instacron:UNENTRO |
| ISSN: | 2175-5620 1518-0352 |
| Popis: | In Brazil, Imunoparvum R° is used as an immunomodulator. It is commercialized in 2 ml ampoules containing 2 mg of Propionebacterium acnes (formerly known as Corynebacterium parvum)/ml, in a 0.5 % phenol and 0.85% sodium chloride solution. High therapeutic power associated to minimum side effects is a great challenge to the pharmaceuticalindustry. Research results have shown that Imunoparvum R° induces side effects in humans and animals, probably because of its phenol content (SOUSA, 1993; RODRIGUES, 2001). The objective of this study was to determine the phenol content of lyophilized and non-lyophilized Imunoparvum R° and to compare their side effects in mice. It was demonstrated that the lyophilization process reduces the phenol content and the side effects of Imunoparvum R°, when compared to the commercialized Propionebacterium acnes suspension. |
| Databáze: | OpenAIRE |
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