Study of the salivary parameters in pacients with picnodysostosis
| Autor: | Couto, José Luciano Pimenta |
|---|---|
| Přispěvatelé: | Fonteles , Cristiane Sá Roriz |
| Jazyk: | portugalština |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC |
| Popis: | Picnodysostosis (PKND) is a skeletal displasia characterized by short stature, osteosclerosis, acrosteolisis, craniofacial deformities and bone fragility. Approximately 200 cases have been described among different ethnic groups, with an estimated incidence of 1.7: 1.000.000 live births. The use of saliva as a diagnostic tool has advanced exponentially within recent years. Unbalance in the amount and composition of saliva may generate oral diseases such as dental caries and periodontitis, and may also indicate important systemic alterations. This study has aimed to investigate the parameters of human whole saliva in patients with PKND. Our study sample consisted of 4 individuals with PKND (experimental group) and 4 healthy individuals without PKND (control group). Salivary flow rate, pH and protein profile were evaluated in this population. Non stimulated whole saliva was collected and centrifuged. The supernatant was separated and lyophilized and stored at -20°C for posterior total protein and bidimensional electroforetic analysis. Statistically significant differences were observed between groups (p |
| Databáze: | OpenAIRE |
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