Effect of metformin on myocardial and renal remodeling in obese rats with insulin resistance
| Autor: | Klajman, Adriana Burlá |
|---|---|
| Přispěvatelé: | Neves, Mário Fritsch Toros, Oigman, Wille, Sanjuliani, Antonio Felipe, Mesquita, Evandro Tinoco, Medeiros, Fernanda Jurema |
| Jazyk: | portugalština |
| Rok vydání: | 2011 |
| Předmět: |
Cardiovascular Disease - Risk factors
Remodelação ventricular Cardiac fibrosis Fibrose endomiocárdica - Etiologia Remodelamento vascular CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::CARDIOLOGIA [CNPQ] Obesidade - Fatores de risco Insulin resistance Metformin - Therapeutic use Kidney diseases - Etiology Resistência à insulina Endomyocardial fibrosis - Etiology Metformina - Uso terapêutico Doenças cardiovasculares - Fatores de risco Nefropatias - Etiologia Metformin Renal disease Obesity - Risk factors Obesidade Fibrose cardíaca Ventricular remodeling Doença renal Vascular remodeling Obesity Metformina |
| Zdroj: | Biblioteca Digital de Teses e Dissertações da UERJ Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
| Popis: | Submitted by Boris Flegr (boris@uerj.br) on 2021-01-05T19:36:14Z No. of bitstreams: 1 Adriana Burla Klajman Tese completa.pdf: 1316186 bytes, checksum: 460b096f78aa4f8100f9f390bc283f00 (MD5) Made available in DSpace on 2021-01-05T19:36:14Z (GMT). No. of bitstreams: 1 Adriana Burla Klajman Tese completa.pdf: 1316186 bytes, checksum: 460b096f78aa4f8100f9f390bc283f00 (MD5) Previous issue date: 2011-06-03 Many evidences show that obesity is associated to structural and functional changes in the heart of human and animal models. Recent studies also show that human obesity is associated with vascular structural and functional modifications, specially at large and medium-sized arteries. Epidemiological studies have confirmed that obesity is a significant risk factor for the development of proteinuria and end-stage renal disease in a normal population. With the objective to determinate morphological changes related to cardiac, vascular and renal remodeling in an experimental model of monosodium glutamate (MSG)-induced obesity and the effect of metformin at this finding. Twenty five rats were studied and divided into five groups: control with 16 e 22 weeks (CON-16 and CON-22); obese with 16 and 22 weeks (MSG-16 e MSG-22), and obese + metformin (MET-22) 300mg/Kg/day per oral. The characterization of insulin resistance was done through measurement of plasma insulin and calculation of HOMA-IR index. The morphological analysis and the quantification of myocardial collagen were carried out by Image Pro Plus analysis system. The systolic blood pressure was slightly higher in MSG-22 group, reaching statistical significance when compared to MSG-16 group (122±2 vs 108±2 mmHg, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|