Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans

Autor:	MENEZES,RAQUEL T., PEREIRA,THAÍS C., JUNQUEIRA,JULIANA C., OLIVEIRA,LUCIANE D., SCORZONI,LILIANA
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	capsule synergistic combination fluconazole Cryptococcus neoformans duloxetine hydrochloride
Zdroj:	Anais da Academia Brasileira de Ciências v.94 n.2 2022 Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências (ABC) instacron:ABC
Popis:	This study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH and FLZ, respectively. The capsule size decreased by 67% ​​and 16% when treated with DH and DH with FLZ, respectively. Therefore, this study showed that DH is active against C. neoformans alone and in combination with FLZ, leading to the reduction of the capsule size of this yeast.
Databáze:	OpenAIRE
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