Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats

Autor: de Rezende, L. Ferreira, Silva da Costa, E. C., Guimaraes Moraes Schenka, N., Almeida Schenka, A., Uemura, Gilberto [UNESP]
Přispěvatelé: Ctr Univ Fac Associadas Ensino FAE, Universidade Estadual de Campinas (UNICAMP), Universidade Estadual Paulista (Unesp)
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Popis: Made available in DSpace on 2013-08-12T18:03:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-07-01 Made available in DSpace on 2013-09-30T19:14:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-07-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:31:24Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T15:31:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-07-01 PAPEC - Centro Universitario das Faculdades Associadas de Ensino - FAE, Sao Joao da Boa Vista, São Paulo, Brazil Purpose: Ultrasound (US) therapy is an elect rot hermotherapeutic modality that uses US energy to provoke physical and chemical alterations. US therapy has been widely used in physical therapy. However in clinical practice, it is contra-indicated in cancer patients due to the possibility of exacerbating tumor growth.Methods: Sixty-eight female Sprague-Dawley rats bred in UNIFAE vivarium were studied. At 50 days of age, 7, 12-dimetylbenz(a)anthracene (7, 12-DMBA) was administered to 35 rats by gastric gavage to induce mammary cancer After 90 days the mammary glands of the rats belonging to the group with mammary cancer induction and stimulated by US were removed. Animals received either continuous or pulsed US. US waves were generated at a frequency of 1 MHz during 10 days, with an intensity dose of 0.5 W in the continuous group, and 0.9 W (duty cycle: 20%) in the pulsed group.Results: Among the rats treated with continuous US, 44.4% developed local recurrence, while among the rats treated with pulsed US, 22.2% had local tumor recurrence (p < 0.05). No evidence of distant metastases was shown in any of the rats studied.Conclusion: The use ofcontinuous and pulsed therapeutic US promoted the development of local recurrence of mammary cancer in female Sprague-Dawley rats in the postoperative period. Ctr Univ Fac Associadas Ensino FAE, Phys Therapy Dept, São Paulo, Brazil Univ Estadual Campinas UNICAMP, Dept Pharmacol, São Paulo, Brazil Univ Estadual Paulista UNESP, Obstet Gynecol & Mastol Dept, São Paulo, Brazil Univ Estadual Paulista UNESP, Obstet Gynecol & Mastol Dept, São Paulo, Brazil
Databáze: OpenAIRE
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