National laboratory surveillance of viral agents of gastroenteritis in Brazil
| Autor: | Pereira, H. G, Linhares, Alexandre da Costa, Candeias, J. A. N, Glass, R. I |
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| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: | |
| Zdroj: | Repositório Digital do Instituto Evandro Chagas (Patuá) Instituto Evandro Chagas (IEC) instacron:IEC |
| Popis: | Department of Virology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. Minist?rio da Sa?de. Funda??o Nacional de Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. University of S?o Paulo. Institute of Biomedical Sciences. Department of Microbiology. S?o Paulo, SP, Brazil. Centers for Disease Control and Prevention. National Center for Infectious Diseases. Division of Viral and Rickettsial Diseases. Respiratory and Enteric Viruses Branch. Viral Gastroenteritis Section. Atlanta, Georgia, U.S.A. In 1984 an enzyme immunoassay for rotavirus and adenovirus developed in the Virology Department of the Oswaldo Cruz Foundation was distributed to laboratories in 14 Brazilian states as part of a proyect to survey viral agents in fecal specimens from children with diarrhea. The ensuing surveillance continued for 3 to 5 years, and in 1991 the results obtained by all laboratories that tested 300 o more fecal specimens were reviewed at a workshop held in Bel?m. These results showed that rotavirus had been detected in 13 percent to 20 percent of the specimens tested, with positive specimens appearing to peak in the May to September "winter" or dray season in Brazil's central and southern states but not in the more tropical northern areas. Adenovirus, detected in 0.7 percent to 5.5 percent of the specimens tested for it, showed no seasonal variations. Many other viral agent know to cause gastroenteritis (e.g., astrovirus, small round-structured viruses, calcivirus, and group C rotavirus) were detected at centers that used electron microscopy. Picobirnavirus, a novel agent no yet associated with gastroenteritis in humans, was found by polyacrylamide gel electrophoresis in specimens from a number of centers using this technique. Vaccines to prevent rotavirus that are currently under development would be of great use in Brazil, where rotavirus is the most common cause of childhood diarrhea. Improved diagnostics will be required to assess the importance of the other viral agents. |
| Databáze: | OpenAIRE |
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