Maternal and postnatal high fat diet provoke adverse liver, pancreas and adipose tissue remodelling in offspring
| Autor: | Gregório, Bianca Martins |
|---|---|
| Přispěvatelé: | Lacerda, Márcia Barbosa Águila Mandarim de, Brunini, Tatiana Marlowe Cunha, Costa, Waldemar Silva, Tibiriçá, Eduardo Vera, Dôres, Sílvia Maria Custódio das |
| Jazyk: | portugalština |
| Rok vydání: | 2010 |
| Předmět: |
Dieta hiperlipídica materna
Adipose tissue remodeling Esteatose hepática Liver steatosis CIENCIAS BIOLOGICAS::MORFOLOGIA [CNPQ] Gestation - Lactation Fetal programming Pancreatic alteration Programação fetal Gestação -Lactação Alterações pancreáticas Maternal high-fat diet C57BL/6 mice Camundongos C57BL/6 Remodelamento do tecido adiposo |
| Zdroj: | Biblioteca Digital de Teses e Dissertações da UERJ Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
| Popis: | Submitted by Boris Flegr (boris@uerj.br) on 2021-01-05T18:07:41Z No. of bitstreams: 1 Tese oficial completa.pdf: 9122139 bytes, checksum: c42f1e82e70f83bc665a2d196ee7de81 (MD5) Made available in DSpace on 2021-01-05T18:07:41Z (GMT). No. of bitstreams: 1 Tese oficial completa.pdf: 9122139 bytes, checksum: c42f1e82e70f83bc665a2d196ee7de81 (MD5) Previous issue date: 2010-07-21 Maternal high-fat diet (HF) during gestation and/or lactation period increases the susceptibility to development of chronic disease in offspring adult life. This work aimed to verify the hypothesis that maternal intake of high-fat diet in critical periods of pregnancy and/or suckling period predisposes to non alcoholic fatty liver disease, pancreatic and adipose tissue alterations in adulthood mice offspring. C57BL/6 female mice were fed, during gestation and/or lactation phases, with standard chow (SC) or HF diet. Male pups were divided into 5 groups: SC- from SC fed dam; G- from HF fed dam during gestation period; L- from HF fed dam during lactation period; GL- from HF fed dam during gestation and lactation periods and GL/HF- from HF fed dam during gestation and lactation, maintaining HF diet from post-weaning to adulthood. We analyzed body mass in all experiment, and at the euthanasia (3 mo-old), liver, pancreas and adipose tissue were removed, weighted and embedded. Blood was collected to biochemical analyses. At birth and at weaning, GL/HF pups were heavier than SC pups (+6% and +44%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|