Perfil dos agentes etiol?gicos detectados em sintom?ticos respirat?rios durante o primeiro ano da pandemia de covid-19

Autor: Varela, Fernanda Hammes
Přispěvatelé: Stein, Renato Telelbom
Jazyk: portugalština
Rok vydání: 2022
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações da PUC_RS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
Popis: Introdu??o: A pandemia da doen?a por coronav?rus 2019 (COVID-19) agregou desafios in?ditos para a comunidade cient?fica e leiga, mas principalmente para as pol?ticas p?blicas de sa?de. A imposi??o de restri??es sociais, de circula??o de pessoas, assim como o uso de m?scara foram pontos focais para as mudan?as epidemiol?gicas das infec??es respirat?rias durante esse per?odo. Objetivo: Descrever a frequ?ncia de pat?genos respirat?rios em pacientes com sintomas compat?veis de COVID-19 durante o per?odo inicial da pandemia no ano de 2020, em dois hospitais no sul do Brasil. M?todos: Pacientes internados e ambulatoriais maiores de 2 meses de idade com sinais e sintomas de COVID-19 agudo (tosse, febre ou dor de garganta) foram prospectivamente inclu?dos de maio a novembro de 2020, em dois hospitais de Porto Alegre - RS, Brasil. Todos os participantes realizaram RT-PCR de resposta r?pida para SARS-CoV-2, Influenza e V?rus Sincicial Respirat?rio (VSR), e al?m desses agentes, os pacientes pedi?tricos realizaram painel de PCR em tempo real que avaliou 20 pat?genos respirat?rios (tr?s bact?rias e 17 v?rus). Resultados: Ao todo foram triados 2011 participantes, sendo 356 exclu?dos (215 recusas em participar, 139 n?o eram eleg?veis, 2 retiradas de consentimento). Desses 1655, 868 foram inclu?dos no Hospital Moinhos de Vento (649 adultos, e 219 menores de 18 anos), e 787 no Hospital Restinga Extremo Sul (566 adultos, e 221 menores de 18 anos). Dos 1655 participantes inclu?dos na amostra final, 1435 participantes tiveram amostra vi?vel para avalia??o de painel para VSR, Influenza A e B. Dos participantes menores de 18 anos inclu?dos, 436 tiveram amostra vi?vel para avalia??o do painel viral-bacteriano ampliado de 20 pat?genos. Dentre os pat?genos identificados o SARS-CoV-2 e o rinov?rus foram os principais agentes encontrados. Um achado importante ? que n?o houve circula??o do VSR e do v?rus Influenza durante este per?odo. Conclus?o: A preval?ncia da maioria dos pat?genos respirat?rios usualmente encontrados nas temporadas de outono e inverno, como V?rus Sincicial Respirat?rio (VSR) e Influenza, foi excepcionalmente baixa nos meses de maio a novembro de 2020, per?odo de importantes restri??es e distanciamento social em resposta ? pandemia de COVID-19. Enquanto esses v?rus desapareceram de circula??o, o rinov?rus e o SARS-CoV-2 foram os principais agentes detectados. Outro achado importante ? de que a COVID-19 foi menos associada ? hospitaliza??o do que a outras infec??es respirat?rias em menores de 18 anos de idade. Introduction: The coronavirus disease 2019 (COVID-19) pandemic has brought unprecedented challenges for the scientific and lay community, but especially for public health policies. The imposition of social restrictions, circulation control, and the use of masks were focal points for the epidemiological changes of respiratory infections during this period. Objective: The aim was to describe the frequency of respiratory pathogens in patients with suspicious COVID-19 during the initial period of the pandemic in the year 2020, in two hospitals in southern Brazil. Methods: Inpatients and outpatients older than 2 months with signs and symptoms of acute COVID-19 (cough, fever or sore throat) were prospectively included in the study from May to November 2020, in two hospitals in Porto Alegre - RS, Brazil. All participants performed RT-PCR for SARS-CoV-2, Influenza, and Respiratory Syncytial Virus (RSV), and in addition to these agents, pediatric patients performed a real-time PCR panel that evaluated 20 respiratory pathogens (three bacteria and 17 viruses). Results: A total of 2011 participants were screened, of which 356 were excluded (215 refused to participate, 139 were ineligible, 2 withdrew consent). Of these 1655, 868 were included in Hospital Moinhos de Vento (649 adults, and 219 under 18 years), and 787 in Hospital Restinga Extremo Sul (566 adults, and 221 under 18 years). Of the 1655 participants included in the final sample, 1435 participants had a viable sample for panel assessment for RSV, Influenza A and B. Of the participants under 18 years of age included, 436 had a viable sample for assessment of the expanded viral-bacterial panel of 20 pathogens. SARS-CoV-2 and rhinovirus were the main pathogens identified. An important finding was the absence of RSV and Influenza virus during this period. Conclusion: The prevalence of most respiratory pathogens usually found in the autumn and winter seasons, such as Respiratory Syncytial Virus (RSV) and Influenza, was exceptionally low in the months of May to November 2020, a period of important restrictions and social distancing in response to the pandemic. While these viruses disappeared from circulation, rhinovirus and SARS-CoV-2 were the main agents detected. Another significant finding is that COVID-19 in symptomatic children was less associated with hospitalization than other respiratory infections in children under 18 years of age. Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES
Databáze: OpenAIRE
Externí odkaz: