Transactions of the Royal Society of Tropical Medicine and Hygiene
| Autor: | Frota, Cristiane C., Freitas, Max V. C., Foss, Norma T., Lima, Luana Nepomuceno Costa, Rodrigues, Laura C., Barreto, Mauricio Lima, Kerr, Ligia Regina Franco Sansigolo |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1016/j.trstmh.2010.03.006 |
| Popis: | Acesso restrito:Texto completo. p.490-495 Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-04T10:49:06Z No. of bitstreams: 1 __ac.els-cdn.com_S003592...68fcd1c5b92c814cda17eaf7d131a.pdf: 90187 bytes, checksum: fd399cb83d5e7697fc31928ae102cc69 (MD5) Made available in DSpace on 2012-05-04T10:49:07Z (GMT). No. of bitstreams: 1 __ac.els-cdn.com_S003592...68fcd1c5b92c814cda17eaf7d131a.pdf: 90187 bytes, checksum: fd399cb83d5e7697fc31928ae102cc69 (MD5) Previous issue date: 2010 The seroprevalence rates of IgM anti-phenolic glycolipid-I (PGL-I) antibodies in four study groups with differing exposure to Mycobacterium leprae in Ceará, Brazil were investigated between March 2005 and August 2006. The first three groups in a high prevalence area included 144 cases of leprosy, their 380 contacts and 317 participants with no known leprosy contact. The fourth group in a low prevalence area consisted of 87 participants with no known leprosy contact living in an area in which no cases of leprosy had been reported in the previous 6 months. Seropositivity and levels of IgM antibodies to PGL-I were investigated using ELISA. The seropositivity levels of anti-PGL-I among the different clinical forms of leprosy cases were 61% for lepromatous, 25% for tuberculoid and 27% indeterminate. The levels of anti-PGL-I antibodies in the endemic area differentiated leprosy cases from noncases. However, the seropositivity was similar among contact cases (15.8%) and no known leprosy contact cases from high (15.1%) and low (13.8%) prevalence areas. The seropositivity of both contacts and no known contacts was much higher than previously reported among no known contacts in other endemic areas. The study indicates that anti-PGL-I antibodies are not useful as immunological markers of household leprosy contacts and no known leprosy contacts in endemic areas. |
| Databáze: | OpenAIRE |
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