Participação do Estado Contrátil e do Relaxamento Miocárdico na Disfunção Ventricular durante a Transição Hipertrofia-Falência Cardíaca
| Autor: | Cicogna, Antonio Carlos [UNESP], Robinson, Kathleen G., Conrad, Chester H., Squire, Robin, Okoshi, Marina Politi [UNESP], Bing, Oscar H. L. |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | portugalština |
| Rok vydání: | 1997 |
| Předmět: |
Male
hypertension Cardiac Output Low Heart failure Rats Inbred WKY Ventricular Dysfunction Left heart contraction heart left ventricle hypertrophy Animals animal rat cardiovascular diseases comparative study pathophysiology Hypertrophy Right Ventricular Wistar Kyoto rat forward heart failure Hypertrophy musculoskeletal system Myocardial Contraction Rats heart right ventricle hypertrophy physiology cardiovascular system heart left ventricle function Myocardial function Hypertrophy Left Ventricular circulatory and respiratory physiology |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:18:18Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:44:35Z : No. of bitstreams: 1 2-s2.0-0031321453.pdf: 144756 bytes, checksum: c7e8e1fd4dc350e2cd6f9380a71b2cdd (MD5) Made available in DSpace on 2014-05-27T11:18:18Z (GMT). No. of bitstreams: 0 Previous issue date: 1997-12-01 Purpose - To investigate the participation of contractile state and relaxation in cardiac muscle dysfunction during the transition from stable hypertrophy to cardiac decompensation in aging spontaneously hypertensive rats (SHR). Methods - isolated left ventricular papillary muscle function was studied in SHR with heart failure (SHR-F), in age-matched SHR without evidence of heart failure (SHR-NF), and in nonhypertensive controls Wistar-Kyoto rats (WKY). Muscles were analised in isometric and isotonic contractions in Krebs-Henseleit solution with calcium concentration of 1.25mM at 28°C. Results - Papillary muscles from SHR-F and SHR-NF demonstrated decreased active tension development and shortening velocity relative to normotensive WKY (p 0.05). Conclusion - These data suggest that the progression from stable hypertrophy to heart failure is associated with changes in the passive stiffness and is not related to depression of myocardial contractile function. Faculdade de Medicina de Botucatu Depto. de Clin. Médica, Rubião Júnior, S/N, 18618-000 - Botucatu, SP Faculdade de Medicina de Botucatu Depto. de Clin. Médica, Rubião Júnior, S/N, 18618-000 - Botucatu, SP |
| Databáze: | OpenAIRE |
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