Transcranial direct current stimulation modulates autonomic nervous system and reduces ambulatory blood pressure in hypertensives

Autor: Rodrigues, Bruno, 1980, Barboza, Catarina de Andrade, Moura, Eliezer Guimarães, 1985, Ferreira-Melo, Sílvia Elaine, Ruberti, Olivia Moraes, 1994, Moreno Junior, Heitor, 1958
Přispěvatelé: UNIVERSIDADE ESTADUAL DE CAMPINAS
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Repositório da Produção Científica e Intelectual da Unicamp
Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP
Popis: Transcranial direct current stimulation (tDCS) seems to positively modulate the autonomic nervous system in different clinical conditions and healthy subjects; however, its effects on hypertensive (HTN) patients are not completely known. This study aimed to evaluate the effects of a tDCS or SHAM session (20 min) on blood pressure (BP) and autonomic variables of HTN patients. Subjects (n = 13) were randomly submitted to SHAM and tDCS sessions (1 week of washout). Hemodynamic and autonomic variables were measured at baseline, during, and immediately after tDCS or SHAM stimulation (Finometer®, Beatscope). Ambulatory BP measurement (ABPM) was evaluated after the experimental period. Hemodynamic variables were not changed by tDCS, except for the fall in peripheral vascular resistance (? = -1696.51 ± 204.65 dyn.s/cm5). After the tDCS, sympathetic modulation was decreased (-61.47%), and vagal modulation was increased (+38.09%). Such acute autonomic changes may have evoked positive results observed in 24 hs-systolic blood pressure (? = -8.4 ± 6.2; P = .0022) and 24hs-diastolic blood pressure (? = -5.4 ± 4.2; P = .0010) in tDCS subjects compared with that in SHAM. These findings suggest that the tDCS could promote positive acute adjustments on cardiac autonomic control and reduced values on 24-hs BP of HTN patients. More than a proof-of-concept, these results may point out to the future, where brain stimulation (tDCS) can be used to HTN syndromes, such as refractory HTN FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ Fechado
Databáze: OpenAIRE
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