Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
| Autor: | Carvalho, Leonardo J. de Moura, Oliveira, S. G., Theisen, M., Alves, F. A., Andrade, M. C. R., Zanini, G. M., Br?gido, Maria do Carmo de Oliveira, Oeuvray, C., P?voa, Marinete Marins, Muniz, Jos? Augusto Pereira Carneiro, Druilhe, P., Daniel-Ribeiro, Claudio Tadeu |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Repositório Digital do Instituto Evandro Chagas (Patuá) Instituto Evandro Chagas (IEC) instacron:IEC |
| Popis: | Funda??o Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Laboratory of Malaria Research. Rio de Janeiro, RJ, Brasil. Minist?rio da Sa?de. Funda??o Nacional de Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Statens Seruminstitut. Clinical Biochemistry. Copenhagen, Denmark. Minist?rio da Sa?de. Funda??o Nacional de Sa?de. Centro Nacional de Primatas. Bel?m, PA, Brasil. Funda??o Oswaldo Cruz. CECAL. Department of Primatology. Rio de Janeiro, RJ, Brazil. Funda??o Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Laboratory of Malaria Research. Rio de Janeiro, RJ, Brasil. Minist?rio da Sa?de. Funda??o Nacional de Sa?de. Centro Nacional de Primatas. Bel?m, PA, Brasil. Institut Pasteur. Biomedical Parasitology. Paris, France. Minist?rio da Sa?de. Funda??o Nacional de Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Funda??o Nacional de Sa?de. Centro Nacional de Primatas. Bel?m, PA, Brasil. Institut Pasteur. Biomedical Parasitology. Paris, France. Funda??o Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Laboratory of Malaria Research. Rio de Janeiro, RJ, Brasil. The immunogenicity and protective efficacy of various antigen-adjuvant fomulations derived either from the merezoite-surface protein-3(MSP-3)or the glutamate-richprotein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These Proteins were selected for immunogenicity studies based primarily on their capacity of inducing an antibody-dependent cellular inhibition effect on parasite growth. Some of the S.sciureus monkeys immunized with MSP-3 212-380 - AS02 or GLURP 27-500 - alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) stain] blodd-stage infection, and thisprotection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection usig adjuvants that are aceptable for human use and this sholud trigger further studies with those new antigens. |
| Databáze: | OpenAIRE |
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