Memórias do Instituto Oswaldo Cruz
| Autor: | Magalhães, Andréa, Miranda, Delfin Gonzalez, Miranda, Roberval Gonzalez, Araujo, Maria Ilma Andrade Santos, Jesus, Adriana Almeida de |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1590/S0074-02762004000900004 |
| Popis: | p. 21-26 Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2013-01-31T18:52:44Z No. of bitstreams: 1 v99s1a04.pdf: 93554 bytes, checksum: 30d846b11b66b92cc0bfdc7c500e1a2e (MD5) Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-02-04T15:41:39Z (GMT) No. of bitstreams: 1 v99s1a04.pdf: 93554 bytes, checksum: 30d846b11b66b92cc0bfdc7c500e1a2e (MD5) Made available in DSpace on 2013-02-04T15:41:40Z (GMT). No. of bitstreams: 1 v99s1a04.pdf: 93554 bytes, checksum: 30d846b11b66b92cc0bfdc7c500e1a2e (MD5) Previous issue date: 2004 This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients.Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-g, tumor necrosis factor-a and transforming growth factors-b) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni. Rio de Janeiro |
| Databáze: | OpenAIRE |
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