Study of neurobiologic components of the sleep in quails (Coturnix japonica) (Temminck Schlegel, 1849) (Birds: Galliformes)

Autor: Polo, Patr?cia de Almeida
Přispěvatelé: Reis, Luis Carlos, Silva, H?lio Ricardo da, Piratelli, Augusto Jo?o, Ferreira, Ildemar, Mendes, Lys Angela Favaroni, Luis Carlos Reis
Jazyk: portugalština
Rok vydání: 2009
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações da UFRRJ
Universidade Federal Rural do Rio de Janeiro (UFRRJ)
instacron:UFRRJ
Popis: Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2022-05-02T18:33:09Z No. of bitstreams: 1 2009 - Patricia de Almeida Polo.pdf: 1032409 bytes, checksum: 53b4b0668b4466242679b8e4b98eefb7 (MD5) Made available in DSpace on 2022-05-02T18:33:09Z (GMT). No. of bitstreams: 1 2009 - Patricia de Almeida Polo.pdf: 1032409 bytes, checksum: 53b4b0668b4466242679b8e4b98eefb7 (MD5) Previous issue date: 2009-03-06 This work gives continuity to an incidental discovery from the Laboratory of Animal Plhysiology of UFRRJ, in the Department of Physiologic Science in which quails were treated periphericaly by serotonin, in a study of feeding behavior became sleep. From this evidence, the idea of which serotonin permeates the blood-brain barrier (BBB) of the birds, differently to mammals, incited new investigations about neuropharmacology and regarding this issue. Firstly, a study of antagonists e agonists of serotonergic receptors was held, confirming the permeability of the barrier of (BBB) of quails to serotonin and your participation in the central mechanisms involved in the regulation of the similar sleep-like behaviors. This research resulted in a publication of a first in the Brazilian Journal of Biology, in 2007, entitled "Behavioral and neuropharmacological evidence that serotonin crosses the bloodbrain barrier in Cortunix japonica (Galliformes: Aves). Taking into consideration that the serotonin is the precursor of melatonin and this last one is involved in the control of the circadian rhythm, we continued with the investigation about the plasma leveis of melatonin, by means of application of the serotonin precursor, L-5-hydroxy-tryptophan. This study resulted in the publication of a second article in the Brazilian Journal of Biology, in 2007, "Nocturnal plasma levels of melatonin in quails (Cortunix japonica) injected with L-5-hydroxy-tryptophan". Once the behaviors related to sleep involves a series of central inhibition and the y-aminobutyric acid (GABA) is the biggest central inhibitory neurotransmitter of the central nervous system, we continued exploring behavioral and neuropharmacologically broaching the one type of gabaergic receptor, aiming the sleep of quails, the complex receptor GABAA. This work resulted in the third and last publication of this doctorate work, "Study of GABAA receptors on the sleep-like behavior in Cortunix japonica (Temminck Schlegel, 1849) (Galliformes: Aves)", in the Journal of Comparative Physiology A, in 2008. Toe aim of this thesis was not to draw a parallel between birds and mammals. However, many evidences were inevitable. Certainly, this research contributed to increase the scientific knowledge of the analysed elements. There is still too much to investigate concerning sleep, not only in birds, but also in mammals. Esse trabalho deu continuidade a um achado incidental do Laborat?rio de Fisiologia Animal da UFRRJ, no Departamento de Ci?ncias Fisiol?gicas, no qual, codornas tratadas perifericamente com serotonina, em um estudo sobre comportamento alimentar, apresentaram comportamentos semelhantes ao sono. A partir dessa evid?ncia, a id?ia de que a serotonina permeia a barreira hematoencef?lica de aves, diferentemente de mam?feros, incitou novas investiga??es neurofarmacol?gicas e comportamentais. Foi realizado, primeiramente, um estudo com antagonistas e agonistas de receptores serotonin?rgicos, confirmando a permeabilidade da barreira hematoencef?lica de codornas ? essa amina biog?nica e sua participa??o em mecanismos centrais envolvidos na regula??o de comportamentos semelhantes aos do sono. Esse trabalho resultou em uma publica??o na Brazilian Joumal of Biology, em 2007, intitulada "Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Gallifonnes: Aves)". Levando-se em considera??o que a serotonina ? precursora da melatonina, e que esta ?ltima est? envolvida no controle do ritmo circadiano, continuou-se a investiga??o, em tomo das altera??es s?ricas de melatonina, mediante administra??o do precursor da serotonina, L-5-hidr?xi-triptofano. Esse estudo resultou na publica??o do segundo artigo na Brazilian Journal of Biology, em 2007, "Nocturnal plasma leveis of melatonin in quails (Coturnix japonica) injected with L-5-hydroxy-tryptophan". Uma vez que os comportamentos relacionados ao sono envolvem uma s?rie de inibi??es centrais e que o ?cido y-amino-but?rico (GABA) ? o maior neurotransmissor central do sistema nervoso central, continuou-se a explorar neurofarmacol?gica e comportamentalmente, o sono em codornas, abordando-se um tipo de receptor gaba?rgico, o complexo receptor GABAA. O estudo resultou na ?ltima publica??o desse doutoramento, Study of GABAA receptors on the sleep-lik:e behavior in Coturnix japonica (Temminck Schlegel, 1849) (Galliformes: Aves), na Joumal of Comparative Physiology A, em 2008. O objetivo dessa tese n?o foi tra?ar um paralelo filogen?tico entre aves e mam?feros, entretanto, muitas evid?ncias foram inevit?veis. Certamente, esse trabalho contribuiu para ampliar o conhecimento cient?fico sobre os elementos estudados. Ainda h? muito o que se investigar a respeito do sono, n?o s? em aves, como tamb?m em mam?feros.
Databáze: OpenAIRE
Externí odkaz: