Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma
| Autor: | Araujo, Maria Ilma Andrade Santos, Hoppe, Bradford, Medeiros Junior, Manoel, Alcântara, Leda Maria, Almeida, Maria Cecilia Freitas de, Schriefer, Nicolaus Albert Borges, Oliveira, Ricardo Riccio, Kruschewsky, Ramon de Almeida, Figueiredo, Joanemile Pacheco de, Cruz Filho, Álvaro Augusto Souza da, Carvalho Filho, Edgar Marcelino de |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1086/425017 |
| Popis: | Texto completo: acesso restrito. p. 1797-1803 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-12-02T13:03:12Z No. of bitstreams: 1 Edgar M. Carvalho.pdf: 444978 bytes, checksum: aaee175489e25d5e75c9f64ca5cd60f2 (MD5) Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2015-06-02T14:12:06Z (GMT) No. of bitstreams: 1 Edgar M. Carvalho.pdf: 444978 bytes, checksum: aaee175489e25d5e75c9f64ca5cd60f2 (MD5) Made available in DSpace on 2015-06-02T14:12:06Z (GMT). No. of bitstreams: 1 Edgar M. Carvalho.pdf: 444978 bytes, checksum: aaee175489e25d5e75c9f64ca5cd60f2 (MD5) Previous issue date: 2004 Helminthic infections have been shown to inhibit allergy skin-prick tests and to modify the course of asthma. We evaluated Dermatophagoides pteronyssinus-specific immune responses in patients with asthma by measuring levels of T helper 2 (Th2) cytokines in peripheral blood mononuclear cell (PBMC) cultures. PBMCs from Schistosoma mansoni-infected patients with asthma living in an area of polyhelminthic endemicity produced lower levels of interleukin (IL)-5 and IL-4 in response to D. pteronyssinus antigen (Ag) 1 than did PBMCs from helminth-free patients with asthma. In contrast, D. pteronyssinus Ag 1-specific production of IL-10 was higher in helminth-infected patients than in helminth-free patients. The addition of recombinant human IL-10 to D. pteronyssinus Ag 1-stimulated cultures of PBMCs from helminth-free patients led to downmodulation of production of IL-5. After helminth-infected patients with asthma received antihelminthic treatment, there was down-modulation of D. pteronyssinus Ag 1-specific production of IL-10 in vitro. S. mansoni-infected patients with asthma produce lower levels of Th2 cytokines than do helminth-free patients with asthma, and this modulation is likely done by IL-10. |
| Databáze: | OpenAIRE |
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