Lupus eritematoso sistêmico: Novo fator de risco para aterosclerose?

Autor: Freire, Beatriz Funayama Alvarenga [UNESP], Da Silva, Rogério Cardoso [UNESP], Fabro, Alexandre Todorovic [UNESP], Dos Santos, Daniela Cristina [UNESP]
Přispěvatelé: Universidade Estadual Paulista (UNESP)
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Popis: Made available in DSpace on 2022-04-29T08:47:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-01-01 OBJECTIVE: To evaluate the prevalence of cardiovascular events (CVE) secondary to atherosclerosis in lupus patients and correlate them to the traditional risk factors, disease duration and drug therapy used. METHODS: A retrospective study was carried out based on data obtained from patients' charts. Patients included were those who had a lupus diagnosis confirmed at least two years before inclusion in the study and had been followed since 1992. CVE were characterized as MI, angina pectoris and stroke non-related to lupus activity. Risk factors and drugs used for treatment were recorded. RESULTS: Seventy-one charts were analyzed. Patients' mean age was 34.2±12.7 years; 68 were women and three were men; 58 were Caucasian (81.6%). Ten (14.08%) presented CVE. Patients in whom CVE were observed were older (42.7 vs. 32.8 years p=0.0021) and presented longer disease duration (10.8 vs. 7.2 years p=0.011). The traditional risk factors, daily and cumulative doses of steroids, immunosuppressive drugs and antimalarial drugs were not significant when patients with and without CVE were compared. CONCLUSION: The prevalence of CVE secondary to atherosclerosis in systemic lupus erythematosus (SLE) was 14.08%. The traditional risk factors were not associated with the development of CVE in lupus patients. Patients that presented cardiovascular events were older and presented longer disease duration. It is a premature conclusion to establish SLE as an independent risk factor for atherosclerosis development. Faculdade de Medicina de Botucatu UNESP, Botucatu, SP Faculdade de Medicina de Botucatu UNESP, Botucatu, SP
Databáze: OpenAIRE
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