Relationship between the Metabolic Syndrome, intramyocellular fat and plasma Adiponectin: role of Rosiglitazone

Autor: Matos, Amélio Fernando de Godoy
Přispěvatelé: Bouskela, Eliete, Aguiar, Luiz Guilherme Kraemer de, Póvoa, Luiz César, Silva, Patrícia Cristina Lisbôa da, Halpern, Alfredo, Oliveira, Jose Egidio Paulo de
Jazyk: portugalština
Rok vydání: 2009
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações da UERJ
Universidade do Estado do Rio de Janeiro (UERJ)
instacron:UERJ
Popis: Submitted by Boris Flegr (boris@uerj.br) on 2021-01-06T20:54:13Z No. of bitstreams: 1 Amelio Fernando Godoy de Matos Completa.pdf: 734273 bytes, checksum: f20e7e27d9b9cc36e2f224aed5afa8e0 (MD5) Made available in DSpace on 2021-01-06T20:54:13Z (GMT). No. of bitstreams: 1 Amelio Fernando Godoy de Matos Completa.pdf: 734273 bytes, checksum: f20e7e27d9b9cc36e2f224aed5afa8e0 (MD5) Previous issue date: 2009-08-18 Insulin resistance (IR) is associated with intramyocellular lipid (IMCL) content and low serum adiponectin (ADP) levels. ADP is also involved in muscle fat oxidation but the relationship between them is still controversial. We aimed to further explore the relationship between ADP and IMCL content in non-diabetic adults and the role of rosiglitazone (RSG) in muscle fat compartment distribution in an adult population of obese nondiabetic metabolic syndrome patients. This study comprises two phases: a cross-sectional and a longitudinal, open-label, drug-interventional one. Laboratory for Clinical and Experimental Research on Vascular Biology (Biovasc) at the State University of Rio de Janeiro. During the cross-sectional phase, 24 obese, nondiabetic patients with metabolic syndrome (MS) and 9 lean healthy controls were studied. Proton nuclear magnetic resonance spectroscopy (1H-NMRS) was performed to quantify IMCL, as well as extramyocellular lipid (EMCL) content. The latter plus serum ADP, anthropometrics and biochemical parameters were evaluated and compared in these two groups. During the longitudinal phase, fifteen of the MS patients were studied by means of 1HNMRS before and after treatment with 8mg/day of RSG for 6 months. Anthropometrical and metabolic variables were assessed. Measurements and main results cross-sectional phase: MS patients had higher body mass index (BMI), waist, waist-to-hip ratio (WHR), glucose, insulin and triglycerides and lower HDL-c as compared to controls. HOMA-IR (3.25 [2.58-4.13] vs 1.02 [0.73-1.29]; p
Databáze: OpenAIRE
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