Antinociceptive activity of mangiferin a glicosilxantona isolated from Mangifera indica L. in mice
| Autor: | Lopes, Synara Cavalcante |
|---|---|
| Přispěvatelé: | Santos , Flávia Almeida |
| Jazyk: | portugalština |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC |
| Popis: | The mangiferin is the major constituent of the leaves and bark of the Mangifera indica L. and has various activities such as antioxidant, immunomodulatory and antiinflammatory properties. This study evaluated the effect of mangiferin, isolated from M. indica, in models of chemical nociception (writhing test induced by acetic acid, formalin test and capsaicin test) and thermal (hot plate test and tail immersion test) in Swiss mice males. We investigated the involvement of the opioid system, TRPV1 and TRP channels, nitric oxide and adenosine receptors in the mechanism of action of mangiferin. Administration of mangiferin (30 and 100 mg/kg, p.o.) and morphine (5 mg/kg, s.c.) significantly reduced (p |
| Databáze: | OpenAIRE |
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