Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalis

Autor:	Moura, Tiane Martin de, Campos, Fabrício Souza, Caierão, Juliana, Roehe, Paulo Michel, D'Azevedo, Pedro Alves, Frazzon, Jeverson, Frazzon, Ana Paula Guedes
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Fatores de virulência VRE Biofi im Enterococcus faecalis Biofilme Resistência à vancomicina Expression
Zdroj:	Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS
Popis:	Introduction: Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome. Methods: Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin. Results: A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro. Conclusions: Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains.
Databáze:	OpenAIRE
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