Factors associated with inspiratory muscle weakness in patients with HIV-1
| Autor: | Jerônimo, Fabiana S., Alves, Giovanni Nardin, Cipriano Junior, Gerson, Vieira, Paulo José Cardoso, Chiappa, Adriana Meira Guntzel, Chiappa, Gaspar Rogério da Silva |
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| Jazyk: | portugalština |
| Rok vydání: | 2015 |
| Předmět: |
Uso terapêutico
Fatores de risco Testes de função respiratória Inspiratory muscle Inflammatory response Efeitos adversos Distribuição aleatória Diaphragm muscle Músculos respiratórios Lung function Fisiopatologia Antiretroviral therapy Teste de esforço Carga viral Fármacos anti-HIV HIV-1 Debilidade muscular Exercise tolerancehighly active Infecções por HIV Fatores de tempo Tratamento farmacológico |
| Zdroj: | Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
| Popis: | Background: the impact of human immunodeficiency virus type 1 (HIV-1) on lung functionis well known and associated with a reduction in pulmonary ventilation. Moreover, theuse of highly active antiretroviral therapy has been associated with mitochondrial dysfunc-tion and decreased muscle strength. However, there is scarce information about the factorsassociated with inspiratory muscle weakness in these patients.Objective: the purpose of the present study was to investigate the factors associated withinspiratory muscle weakness in patients with HIV-1.Methods: two-hundred fifty seven patients with HIV-1 were screened and categorized intotwo groups: (1) IMW+ (n = 142) and (2) IMW− (n = 115). Lung function (FEV1, FVC andFEV1/FVC), maximum inspiratory pressure, distance on the six-minute walk test and CD4cell count were assessed.Results: the mean duration of HIV infection was similar in the two groups. The follow-ing variables were significantly different between groups: mean duration of highly activeantiretroviral therapy (81 ± 12 in IMW+ versus 38 ± 13 months in IMW−; p = 0.01), and CD4cell count (327 ± 88 in IMW+ versus 637 ± 97 cells/mm3in IMW−; p = 0.02). IMW+ presentedreduced lung function (FEV1, FVC, FEV1/FVC).Conclusion: patients with IMW+ had lower distance on the six-minute walk test in com-parison to the IMW− group. The duration of highly active antiretroviral therapy, distancetraveled on the 6MWT and CD4 count were determinants of IMW in patients with HIV. |
| Databáze: | OpenAIRE |
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