Atherosclerosis
| Autor: | Correia, Luis Cláudio Lemos, Magalhães, Luiz P., Braga, Julio Cesar Vieira, Rocha, Mário S., Lima, José Carlos, Passos, Luiz C. S., D'Oliveira Junior, Argemiro, Esteves, José Péricles, Spósito, Andrei C. |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1016/j.atherosclerosis.2004.05.026 |
| Popis: | Trabalho completo: acesso restrito, p. 71–76 Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-09-17T17:04:49Z No. of bitstreams: 1 (207).pdf: 85368 bytes, checksum: 82bed371c2bb892613464267b94ce201 (MD5) Made available in DSpace on 2012-09-17T17:04:49Z (GMT). No. of bitstreams: 1 (207).pdf: 85368 bytes, checksum: 82bed371c2bb892613464267b94ce201 (MD5) Previous issue date: 2004-11 Both increase and decrease of plasma triglycerides during acute coronary syndromes (ACS) are reported, however, a clinical relevance for these distinct metabolic responses is unclear. To test the association between distinct responses of lipid metabolism and cardiovascular risk, 39 subjects admitted with non-ST elevation ACS within 48 h of presentation had plasma lipids measured on the first and sixth days of hospitalization, and continuous electrocardiogram was performed during the first 2 days to quantify recurrent ischemia and heart rate variability. No lipid-lowering therapy was offered to the patients. During the first 5 days, half of them experimented a decrease in triglycerides (n = 19, median: −18 mg/dl) and the other half presented triglyceride increase (n = 20, median: +44 mg/dl). A higher incidence of recurrent ischemia (35% versus 5%, P = 0.02) and greater ischemic burden/patient (123 ± 286 mm min versus 47 ± 212 mm min, P = 0.02) were observed in subjects with triglyceride reduction, when compared with those with triglyceride increase. Individuals with heart rate variability below the median presented a median decrease in triglycerides during the 5-day period, as opposed to the counterparts (P = 0.05). In conclusion, triglyceride reduction during ACS is associated with a greater incidence of recurrent ischemia and may constitute a sign of higher sympathetic activity. |
| Databáze: | OpenAIRE |
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