Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
| Autor: | Silva, M. [UNESP], Lara, A. S., Leite, C. Q.F. [UNESP], Ferreira, E. I. |
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| Přispěvatelé: | Universidade Estadual Paulista (UNESP), Universidade de São Paulo (USP) |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: | |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2022-04-28T18:54:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2001-07-16 With the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug. Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, CP502, 14801-902, Araraquara - SP Faculdade de Ciências Farmacêuticas Universidade de São Paulo, CP 05508-970 Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, CP502, 14801-902, Araraquara - SP |
| Databáze: | OpenAIRE |
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