Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas

Autor: Mainetti, Leandro Ernesto, Rico, María José, Fernández Zenobi, María Virginia, Perroud, Herman A., Roggero, Eduardo, Rozados, Viviana R., Scharovsky, O. Graciela
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: RepHipUNR (UNR)
Universidad Nacional de Rosario
instacron:UNR
Popis: Metronomic chemotherapy (MCT) involves the chronic administration of doses of chemotherapy drugs that are below the maximum tolerated dose (MTD), at frequent and regular intervals, without extended rest periods [1]. It aims to achieve a balance between efficacy in tumor killing and lack of toxicity. The inhibition of angiogenesis would explain its therapeutic effect [2, 3]. We have demonstrated the antitumor efficacy of MCT with cyclophosphamide (Cy) as a single drug [4] and in combination with celecoxib on mice mammary adenocarcinomas (MA) [5]. Considering the high incidence of mammary tumors in humans, in this study, we analyze the therapeutic efficacy, toxicity and mechanism/s of action of MCT combining Cy and doxorubicin (Dox), in mouse MA tumor-models. Fil: Mainetti, Leandro Ernesto. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Argentina Fil: Mainetti, Leandro Ernesto. Departments of Urology and Pathology. Wayne State University School of Medicine; Detroit; MI; USA Fil: Rico, María José. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina Fil: Fernández Zenobi, María Virginia. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina Fil: Perroud, Herman A. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina Fil: Roggero, Eduardo. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina Fil: Rozados, Viviana R. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina Fil: Scharovsky, Graciela Olga. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina
Databáze: OpenAIRE
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