Biomarkers of placental redox imbalance in pregnancies with preeclampsia and consequent perinatal outcomes
| Autor: | Ferreira, Raphaela Costa |
|---|---|
| Přispěvatelé: | Goulart, Marilia Oliveira Fonseca, Oliveira, Alane Cabral Menezes De, Bueno, Nassib Bezerra, Borbely, Alexandre Urban, Mello, Carolina Santos |
| Jazyk: | portugalština |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Repositório Institucional da Universidade Federal de Alagoas (UFAL) Universidade Federal de Alagoas (UFAL) instacron:UFAL |
| Popis: | Objective: To compare redox and inflammatory markers between normal and Pre-Eclampsia (PE)-derived placentas and to evaluate the relationship between placental redox imbalance markers and perinatal outcomes in pregnancies with PE. Methods: This was a cross-sectional study conducted at the maternity hospital of a university hospital in Maceio-Alagoas, Brazil, in 2017, including women diagnosed with PE and healthy pregnant women and their conceptuses. After screening, standardized questionnaires containing socioeconomic, clinical, obstetric and anthropometric data were applied. After delivery, placental samples were collected for quantification of biomarkers of redox imbalance (catalase – CAT; malondialdehyde – MDA; hydrogen peroxide – H2O2; superoxide dismutase – SOD; reduced glutathione – GSH; oxidized glutathione – GSSG; and their ratio – GSH/GSSG) and inflammation (myeloperoxidase – MPO; interleukin (IL)-6; IL-8; IL-10; and tumor necrosis factor-alpha – TNF-α). All biomarkers were evaluated via linear regression with adjustments of variables with measures of weight, length, head circumference (HC), chestcircumference (CC) and gestational age of newborns at birth, considering p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|