Short-time dynamics of helix-coil transition in polypeptides
| Autor: | Arashiro, Everaldo, Felício, José Roberto Drugowich de, Hansmann, Ulrich H. E. |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Zdroj: | Repositório Institucional da UFOP Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
| Popis: | We study the critical relaxation of the helix-coil transition in all-atom models of polyalanine chains. We show that at the critical temperature the decay of a completely helical conformation can be described by scaling relations that allow us estimating the pertinent critical exponents. The present approach opens a new way for characterizing transitions in proteins and may lead to a better understanding of their folding mechanism. An application of the technique to the 34-residue human parathyroid fragment PTH(1-34) supports universality of the helix-coil transition in homopolymers and (helical) proteins. |
| Databáze: | OpenAIRE |
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