Efeito espasmolídico do Óleo essencial de Lippia Sidoides e do Carvacrol no músculo liso de fundo de estômago de rato: investigação da participação dos canais de cálcio operados por voltagens
| Autor: | Silva, Francisco Rafael Oliveira da |
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| Přispěvatelé: | Souza, Emmanuel Prata de, Soares, Pedro Marcos Gomes |
| Jazyk: | portugalština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC |
| Popis: | Lippia sidoides is a medicinal plant of the family Verbenaceae with diverse pharmacological activities among them antispasmodic. Many species of the family Verbenaceae demonstrate in their composition essential oils, endowed with biological activities, thus arousing great pharmacological interest because they present activity on the smooth musculature. Based on these premises, the objective of this work was to investigate the spasmolytic effect of essential oil (OEL) of Lippia sidoides and carvacrol on the smooth muscle of the stomach of the rat. The records were obtained from isolated strips of stomach in preparations for isolated organs through a data acquisition system. Cumulative OEL concentrations (1-300 μg / ml) were added to the bottom of the rat stomach under the effect of the carbachol (CCh) and potassium chloride (KCl) contractors. In the pre-contracted stomach with 60 mM KCl, the shrinkage was reduced to 50% (36.82146 ± 7.9157), 80% (20.83054 ± 7.32411) and 100% (-10.95499 ± 7.73396) at the concentrations of 30, 100 and 300 μg / ml (p |
| Databáze: | OpenAIRE |
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