N-(2-mercaptopropionyl)-glycine but not Allopurinol prevented cigarette smoke-induced alveolar enlargement in mouse
| Autor: | Pires, Karla Maria Pereira, Bezerra, Frank Silva, Machado, Mariana Nascimento, Zin, Walter Araújo, Porto, Luís Cristovão de Moraes Sobrino, Valença, Samuel dos Santos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFOP Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
| Popis: | We investigated the possible protective effects of the Allopurinol (A), N-(2-mercaptopropionyl)-glycine (M) and N-acetylcysteine (N) against lung injury caused by long-term exposure to cigarette smoke (CS) in mouse. C57BL6 mice were exposed to 12 cigarettes a day for 60 days and concomitantly treated with either one of the antioxidant drugs diluted in saline (CS + A—50 mg/kg; CS + M—200 mg/kg/day; CS + N—200 mg/kg/day). Control groups were sham-smoked (AA). Long-term CS exposure results in extensive parenchyma destruction in CS group. Both CS + N and CS + M groups showed preserved alveolar structure and showed preserved lung function when compared to CS group. Macrophage and neutrophil counts were decreased in CS + M, and CS + N groups when compared to CS group (p < 0.05). Antioxidant enzyme activities were reduced in all treated groups. CS + A showed the highest reduction in catalase activity (−25%, p < 0.01). We conclude that M treatment reduced long-term CS-induced inflammatory lung parenchyma destruction and lung function, comparable to N treatment, however, antioxidant administration did not reverse CS-induced antioxidant enzyme activity reduction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|