Calcium anti-obesity therapy: role of vitamin D in the adipocyte
| Autor: | Nobre, Jessica Lopes |
|---|---|
| Přispěvatelé: | Oliveira, Elaine de, Moura, Egberto Gaspar de, Silva, Patrícia Cristina Lisbôa da, Daleprane, Júlio Beltrame, Ortiga, Tania Maria Ruffoni, Bressan, Josefina |
| Jazyk: | portugalština |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Biblioteca Digital de Teses e Dissertações da UERJ Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
| Popis: | Submitted by Boris Flegr (boris@uerj.br) on 2021-01-06T20:54:11Z No. of bitstreams: 1 TESE_FINAL_PUBLICADA_Jessica_Lopes_nobre.pdf: 1744205 bytes, checksum: 37b25eb634ba1d2a2639627f2f57a89f (MD5) Made available in DSpace on 2021-01-06T20:54:11Z (GMT). No. of bitstreams: 1 TESE_FINAL_PUBLICADA_Jessica_Lopes_nobre.pdf: 1744205 bytes, checksum: 37b25eb634ba1d2a2639627f2f57a89f (MD5) Previous issue date: 2015-09-30 Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro Obesity is a worldwide epidemic and in Brazil more than 50% of people are overweight/obese. We show that a rich calcium diet has an anti-obesity effect in obese animals programmed by early weaning (EW), an effect mediated by vitamin D action, which appears to directly regulate adipogenesis. Thus, we decided to evaluate the effect of vitamin D on the metabolism of adipose tissue in vivo with EW animals and in vitro with 3T3L1 lineage. At birth, lactating rats were divided into: EW Group, dams were wrapped with a bandage to interrupt lactation in the last 3 days of lactation; C Group, dams whose pups had free access to breast milk during the lactation period (21 days). At 120 days-old, EW offspring were subdivided into: EW standard diet; EW, received calcium supplementation (EWCa, calcium carbonate 10g / kg chow). We also use 3T3L1 cell line to incubated with calcitriol (1,25 (OH) 2D) or leptin. Significance level was at p |
| Databáze: | OpenAIRE |
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