American Journal of Tropical Medicine and Hygiene
| Autor: | Oliveira, Luiz Fabiano Borges, Báfica, Andre Luiz Barbosa, Rosato, Andréa Bomura, Favali, Cecilia Beatriz Fiuza, Costa, Jackson Mauricio Lopes, Café, Virginia, Barral-Netto, Manoel, Barral, Aldina Maria Prado |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.4269/ajtmh.2011.10-0680 |
| Popis: | Texto completo: acesso restrito. p. 70-73 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-15T13:37:08Z No. of bitstreams: 1 Fabiano Oliveira.pdf: 482368 bytes, checksum: e0d829c00156196053624ac79a76f2b8 (MD5) Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2015-05-04T15:16:01Z (GMT) No. of bitstreams: 1 Fabiano Oliveira.pdf: 482368 bytes, checksum: e0d829c00156196053624ac79a76f2b8 (MD5) Made available in DSpace on 2015-05-04T15:16:01Z (GMT). No. of bitstreams: 1 Fabiano Oliveira.pdf: 482368 bytes, checksum: e0d829c00156196053624ac79a76f2b8 (MD5) Previous issue date: 2011 Cutaneous leishmaniasis (CL) is a worldwide disease endemic in several regions of the globe. The hallmark of CL is skin ulcers likely driven by efforts of the immune system to control Leishmania growth. Cytokines, such as tumor necrosis factor (TNF) and interferon-gamma can control disease progression in animal models. Nevertheless, the impact of these cytokines in CL ulcer outcome is not well established in humans. In this study, 96 CL patients from an endemic area of Leishmania braziliensis were enrolled for a follow-up study that consisted of clinical and immunological evaluations in a 2-year period. Statistical analysis revealed that healing time (P = 0.029), age (P = 0.002), and TNF levels (P = 0.0002) positively correlate with ulcer size at the time of the first clinical evaluation. Our findings suggest that ulcer size correlates with healing time and TNF levels support the use of TNF inhibitors combined with standard therapy to improve healing in CL patients with severe lesions. |
| Databáze: | OpenAIRE |
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