Pharmacology Biochemistry and Behavior

Autor: Magrani, Janeide, Silva, Emilio de Castro e, Varjão, Bruno, Duarte, Gleison Vieira, Ramos, Ana Claudia, Athanazio, Rodrigo Abensur, Barbetta, Marcelo Campos, Luz, Patricia, Fregoneze, Josmara Bartolomei
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Zdroj: Repositório Institucional da UFBA
Universidade Federal da Bahia (UFBA)
instacron:UFBA
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2004.07.004
Popis: p. 189-198 Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-11-08T19:32:36Z No. of bitstreams: 1 1-s2.0-S0091305704002461-main.pdf: 576313 bytes, checksum: af4078d7cac9e336a17bd195c14b8f89 (MD5) Made available in DSpace on 2012-11-08T19:32:37Z (GMT). No. of bitstreams: 1 1-s2.0-S0091305704002461-main.pdf: 576313 bytes, checksum: af4078d7cac9e336a17bd195c14b8f89 (MD5) Previous issue date: 2004 The aim of the present study was to investigate the effect of the pharmacological blockade of histamine H1 and H2 receptors located within the ventromedial hypothalamus (VMH) on overnight food and water intake and on water intake elicited by two physiological stimuli: hyperosmolarity induced by an acute intragastric salt load and water deprivation. During the overnight period, the pharmacological blockade of both H1 and H2 VMH receptors significantly increased food intake and decreased water intake. In hyperosmotic rats, the blockade of H1 VMH receptors reduced water intake, while the blockade of H2 receptors in this same region yielded no significant effect. Additionally, in water-deprived rats, the blockade of both H1 and H2 receptors located within the VMH induced a significant decrease in water intake. The inhibitory effects on drinking behavior observed in this study do not seem to be a consequence of any billness-inducingQ effect provoked by the central administration of the antihistaminergic agents employed here, because an aversion test indicated that the injection of those compounds into the VMH does not induce any billness-likeQ effect. In addition, the central administration of either mepyramine or cimetidine to dehydrated and hyperosmotic rats did not produce any reduction in locomotor activity measured in an openfield arena. Injections of the antihistaminergic agents used here into the regions that circumscribe the VMH produced no significant effects on water or food intake, indicating that the actions observed here may be specifically attributed to the set of histaminergic receptors situated within the VMH.
Databáze: OpenAIRE
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