RuCl3/ PPh3 : catalyzed direct conversion of isoxazol-5-ones to 2,3-disubstituted pyridines

Autor:	Fernandes, Alessandra Aparecida de Godoy, 1993, Stivanin, Mateus Lançanova, 1993, Jurberg, Igor Dias, 1984
Přispěvatelé:	UNIVERSIDADE ESTADUAL DE CAMPINAS
Rok vydání:	2019
Předmět:	Isoxazolones Pyridines Piridinas Descarboxilação Artigo original N-heterocycles N-heterociclos Decarboxylation Ruthenium
Zdroj:	Repositório da Produção Científica e Intelectual da Unicamp Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP
Popis:	Agradecimentos: The authors are grateful to Fapesp for a Ph.D. fellowship to A.A.G.F. (2017/22164-6) and a research grant to I.D.J. (2017/24017-0); and to Faepex-Unicamp for a M.Sc. fellowship to M. L. S. (127/16). The authors thank Mr. Pedro Henrique Vendramini (Unicamp, Brazil) for assistance with HRMS analyses Abstract: A novel catalytic system employing RuCl3/ PPh3 is described for the preparation of 2,3-disubstituted pyridines starting from 3,4-disubstituted isoxazol-5-ones and acrolein. Mechanistic studies involving 31P NMR, HRMS analyses and control experiments have been performed in order to support key events and intermediates proposed for this transformation FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP Fechado
Databáze:	OpenAIRE
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