Effects of the supplementation of magnesium on blood pressure, intracellular cations, insulin resistance in hypertensive patients using hydrochlorothiazide
| Autor: | Maluly, Valter Gabriel |
|---|---|
| Přispěvatelé: | Sanjuliani, Antonio Felipe, Francischetti, Emílio Antonio, Abreu, Virgínia Genelhu de, Soares, Eliane de Abreu |
| Jazyk: | portugalština |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Biblioteca Digital de Teses e Dissertações da UERJ Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
| Popis: | Submitted by Boris Flegr (boris@uerj.br) on 2021-01-06T20:58:49Z No. of bitstreams: 1 Valter Gabriel Maluly Completa.pdf: 713901 bytes, checksum: 0f362613ef0379e732174b5980a516a1 (MD5) Made available in DSpace on 2021-01-06T20:58:49Z (GMT). No. of bitstreams: 1 Valter Gabriel Maluly Completa.pdf: 713901 bytes, checksum: 0f362613ef0379e732174b5980a516a1 (MD5) Previous issue date: 2009-04-29 Context: there are many scientific evidences that magnesium plays a very important role in the physiologic regulation of the blood pressure and glucose metabolism. The alterations of the intracellular homeostasis of this cation, could participate in a very important way in the physiopathologic mechanisms that contribute to the development of arterial hypertension and insulin resistance. Magnesium can influence the blood pressure by modulating the tonus and vascular structure and many effects in biochemical reactions that can control the vascular contractility, the inflammation and the insulin sensibility. Many trials aim that a long term use of diuretic in the treatment of hypertension can induce a depletion of intracellular magnesium. Objectives: to evaluate the effect of oral supplementation of magnesium in hypertension, the intra-erythrocyte concentration of magnesium and sodium and the insulin resistance in primary hypertensive patients treated with thiazidic diuretic. Study design: a randomized, double blind clinical trial was performed. Thirty nine primary hypertensive patients in first stage were distributed in two groups. One group received 20 patients and the other 19. After a period of wash out of two weeks one group received thiazidic diuretic (25mg) and magnesium (240mg of element magnesium) and the other group received thiazidic diuretic (25mg) and placebo during 16 weeks. The patients were evaluated once a month. In the visit 1 (after wash out) and visit 5 (final of the study), they were evaluated in their blood pressure by AMBP (ambulatory monitoring of blood pressure), the intracellular concentration of magnesium and sodium and of the insulin sensibility. In the visit 2 and visit 4, the patients were clinically evaluated and the blood pressure was measured by auscultatory method. Methods: the blood pressure evaluation was made by auscultatory method and AMBP (ambulatory monitoring of blood pressure by space labs). The intra-erythrocyte concentration of magnesium was made by atomic absorption and the concentration of sodium by flame photometer. The plasmatic insulin was measured by radioimmunoassay and the index of insulin resistance by the formulae of homeostatic model evaluation (HOMA). Results: after 16 weeks using diuretic plus magnesium or diuretic plus placebo we observed significative reduction of the blood pressure evaluated by auscultatory method and by ambulatory monitoring blood pressure (AMBP) during 24 hour in the two groups; although there was no significative difference between the reductions of the blood pressure when we compare the two groups. In the group with diuretic plus placebo the reduction of the blood pressure was of 22,30 ±2,44mmhg (p |
| Databáze: | OpenAIRE |
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