Evaluation of latent tuberculosis and risk factors for the development of active tuberculosis in workers in a prison unit in Western Paulista

Autor: AGUIAR, Amanda Aparecida Silva de
Přispěvatelé: Lordelo , Eliana Peresi, Mendes , Rinaldo Poncio, Carvalho, Thais Batista de
Jazyk: portugalština
Rok vydání: 2020
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações da UNOESTE
Universidade do Oeste Paulista (UNOESTE)
instacron:UNOESTE
Popis: Submitted by Jakeline Ortega (jakortega@unoeste.br) on 2021-03-10T15:05:31Z No. of bitstreams: 2 Amanda Aparecida Silva Aguiar.pdf: 2711906 bytes, checksum: db54aa3329d4fbbc221d54fd6e1d8a7d (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Made available in DSpace on 2021-03-10T15:05:31Z (GMT). No. of bitstreams: 2 Amanda Aparecida Silva Aguiar.pdf: 2711906 bytes, checksum: db54aa3329d4fbbc221d54fd6e1d8a7d (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2020-03-13 Tuberculosis (TB) is a disease with a high prevalence in individuals associated with the prison system, such as prison staff. Exposure to Mycobacterium tuberculosis (M. tuberculosis) increases the risk of latent TB, which, associated with risk factors, increases the chance for the development of active TB. The diagnosis of latent TB is made through the tuberculin test (PPD), but it has limitations regarding its effectiveness and interpretation. Currently, IFN-γ (IGRAs) release assays have been implemented, which evaluate the response of CD4 + T and CD8 + T cells against M. tuberculosis antigens, showing better results in relation to PPD. In Brazil, there are few studies evaluating latent TB through IGRAs and their association with risk factors in prison staff, so this study aims to better understand this dynamic. Thus, the objective of the study was to evaluate latent TB and the risk factors for the development of active TB in prison unit servers. For this purpose, prison staff (n = 88) from the Junqueirópolis Penitentiary Unit were studied to assess latent TB, the QFT-TB and PPD tests were performed, for the assessment of risk factors, the KAP questionnaire was applied to TB knowledge assessment, from the DASS 21 questionnaire for mental health assessment. The participants' lipid profile was also assessed. For the evaluation of the questionnaire, the analysis of the frequencies of the variables was performed, considering the TB-latent, latent TB with risk factor and risk factor as an independent variable, and blood lipids were collected to assess the lipid profile for measurement of total cholesterol, HDL and triglycerides. Anthropometric measurements (weight, height and abdominal circumference) were also measured, abdominal fat assessment was performed by measuring waist circumference (WC) and BMI was calculated according to WHO guidelines. The agreement between results of the PPD and QFT-TB Gold tests was measured using the kappa statistic (κ), with a 95% confidence interval (CI) and for the comparison of the dependent variable categories according to the independent variable, it was used the chi-square or Fisher's test, with statistical significance for p
Databáze: OpenAIRE
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