Adhesion, invasion and apoptosis inducing for group B streptococci in respiratory epithelial cells A549
| Autor: | Costa, Andréia Ferreira Eduardo da |
|---|---|
| Přispěvatelé: | Ferreira, Prescilla Emy Nagao, Ignacio, Ana Claudia de Paula Rosa, Figueiredo, Camila Castro, Bôas, Maria Helena Simões Villas, Carvalho, Técia Maria Ulisses de |
| Jazyk: | portugalština |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Biblioteca Digital de Teses e Dissertações da UERJ Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
| Popis: | Submitted by Boris INFORMAT (boris@uerj.br) on 2021-04-26T01:16:14Z No. of bitstreams: 1 DISSERTACAO_FINAL_PUBLICADA_Andreia_Ferreira_Eduardo_da_Costa.pdf: 931285 bytes, checksum: 25eef21f6d4a1d59e336636fe30f171e (MD5) Made available in DSpace on 2021-04-26T01:16:14Z (GMT). No. of bitstreams: 1 DISSERTACAO_FINAL_PUBLICADA_Andreia_Ferreira_Eduardo_da_Costa.pdf: 931285 bytes, checksum: 25eef21f6d4a1d59e336636fe30f171e (MD5) Previous issue date: 2009-03-12 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Group B streptococci (GBS), mainly serotype III, is a major cause of neonatal pneumonia, sepsis and meningitis. Virulence potential of GBS strains may determine the outcome of host colonization or infection. Because the lung constitutes a first step in GBS systemic invasion processes, we have investigates the adherence and invasion mechanisms of GBS-III isolates to human lung epithelial cell line (A549). Thus, the main objective of this study was to evaluate the ability of adhesion and invasion of GBS strains serotype III (90356-liquor and 80340-vagina) with A549 lung epithelial cells, intracellular bacterial persistence, fusion with acidic compartments, cytotoxic potential, and induction of apoptosis. The strains showed ability to adhere and invade the epithelial A549 cells; GBS 90356-liquor isolated from a patient showed a more efficient adherence and invasion properties than GBS-III 80340 isolated from vagina (P |
| Databáze: | OpenAIRE |
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