Factors associated with pulse wave velocity in a cohort of patients with cardiovascular risk factors

Autor: Lelis, Ellen de Souza
Přispěvatelé: Vitorino, Priscila Valverde de Oliveira, Ramos, Gabrielly Craveiro, Correa, Krislainy de Sousa, Souza, Weimar Kunz Sebba Barroso de
Jazyk: portugalština
Rok vydání: 2019
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações da PUC_GOAIS
Pontifícia Universidade Católica de Goiás (PUC-GO)
instacron:PUC_GO
Popis: Submitted by admin tede (tede@pucgoias.edu.br) on 2021-08-19T17:43:56Z No. of bitstreams: 1 Ellen de Souza Lelis.pdf: 1063716 bytes, checksum: e727be0d633d95ee37b0c9b88aecbb63 (MD5) Made available in DSpace on 2021-08-19T17:44:11Z (GMT). No. of bitstreams: 1 Ellen de Souza Lelis.pdf: 1063716 bytes, checksum: e727be0d633d95ee37b0c9b88aecbb63 (MD5) Previous issue date: 2019-03-20 (VOP), obtained by the central blood pressure measure (MCPA). Objective: to analyze the factors associated with PWV in patients with CVD. Methods: Retrospective cohort study performed by means of patient charts. Data regarding the presence of cardiovascular risk factors (CVRF), medication dosage and blood laboratory test results, carotid doppler and echocardiogram were taken from the medical records. Participants were divided into two groups, according to the initial OPV value: G1 those with OPV 10m/s. The possible associated factors were evaluated after the interval of one to two years of the first MCPA measurement. In order to compare the socioeconomic, clinical and clinical variables of G1 and G2 patients in the initial evaluation, chi-square or Fisher and unpaired t-test. Logistic regression analysis was performed to verify the association of CVRF, class of medications, blood pressure control, laboratory and imaging tests with increased OPV (OPV >10m / s). Results: A total of 101 patients were evaluated, 56.0% female. The prevalence of systemic arterial hypertension (SAH) of 80.2% (n = 81), dyslipidemia (DLP) was 65.6% (n = 66), 36.6% (n = 37) and diabetic testis mellitus 18.0% (n = 18). In the initial evaluation, 81.2% of the patients had POC 10m were higher in patients who used statin (OR: 4.03; p = 0.013); (OR: 4.03, p = 0.004) and in those who used three antihypertensives (OR: 11.4, p = 0.045). When the model was adjusted for age, only statin use remained associated with increased OPV (OR: 4.04; p = 0.032). There was a correlation between age and PWV. Conclusion: The increase in OPV was positively associated with pa- tients using statin. VOP shows a strong correlation with age (r = 0.9475, p 10m/s. Os possíveis fatores associados foram avaliados após o intervalo de um a dois anos da primeira MCPA. Para comparar as variáveis socioeconômicas, clínicas e as classe dos medicamentos entre pacientes do G1 e G2 na avaliação inicial foram utilizados testes de quiquadrado ou Fisher e teste de t não pareado (p 10m foi maior em pacientes que usavam estatina (OR: 4,03; p=0,013); nos que utilizavam dois anti-hipertensivos (OR: 4,03; p=0,004) e naqueles que utilizavam três anti-hipertensivos (OR: 11,4; p=0,045). Quando o modelo foi ajustado pela idade apenas o uso de estatina permaneceu associado ao aumento da VOP (OR: 4,04; p=0,032). O aumento da VOP associou-se positivamente com pacientes em uso de estatina em pacientes com dislipidemia e aterosclerose, provavelmente devido às alterações prévias da estrutura da parede arterial. A VOP apresenta forte correlação com a idade (r=0,9475; p
Databáze: OpenAIRE
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