Keloid treatment using postoperative radiotherapy with electron beams: A comparative randomized study of two methods

Autor: de Oliveira Junior, Batista [UNESP], Schellini, Silvana Artioli [UNESP], Lastória, Joel Carlos [UNESP], de Carvalho, Lídia Raquel [UNESP], Stolf, Hamilton Ometto [UNESP], de Oliveira, Ana Laura Paludetto
Přispěvatelé: Universidade Estadual Paulista (UNESP), Universidade José do Rosário Vellano (Unifenas)
Jazyk: portugalština
Rok vydání: 2013
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Popis: Made available in DSpace on 2022-04-29T07:11:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-06-28 Introduction: While several keloid treatment modalities exist, they all offer disappointing results when performed in isolation. The combination of surgical excision and post-operative irradiation with electron beams is effective in improving the quality of scars and reducing the recurrence rate of the condition. Objective: To assess, on a comparative basis, the prospects for cure, and also side effects in the irradiated areas of two treatment methods using electron beams.Methods: A prospective, comparative and randomized clinical study was carried out at the Faculdade de Medicina de Botucatu-UNESP, in Botucatu (SP), Brazil, between 2008 and 2010. The study included patients who were post-operative after their treatment for the resection of keloids. The study population was divided into groups G1 and G2, having received radiotherapy treatment with electrons from a linear accelerator at 30 Gy/10 fractions and 32 Gy/16 fractions, respectively.The patients were followed up with for 18 months. Results were assessed through the observation of two independent evaluators and the distribution of a questionnaire to study participants. Results: Forty-three patients were investigated (21in G1 and 22 in G2). 52.4% showed good results in G1, with a recurrence rate of 47.6%. In G2, 91% showed good results, with a 9% recurrence rate. Conclusion: The 32 Gy/16 fractions method was proved to be superior to the 30 Gy/10 fractions method, resulting in a better therapeutic response and fewer side effects. Serviço de Radioterapia do Hospital das Clínicas Faculdade de Medicina de Botucatu Universidade Estadual Paulista (Unesp), Botucatu (SP) Departamento de Oftalmologia da Faculdade de Medicina Botucatu da Universidade Estadual Paulista (Unesp), Botucatu (SP) Departamento de Dermatologia e Radioterapia Faculdade de Medicina de Botucatu da Universidade Estadual Paulista (Unesp), Botucatu (SP) Departamento de Bioestatística Instituto Básico Universidade Estadual Paulista (Unesp), Botucatu (SP) Faculdade de Medicina Universidade José do Rosário Vellano (Unifenas), Alfenas (MG) Serviço de Radioterapia do Hospital das Clínicas Faculdade de Medicina de Botucatu Universidade Estadual Paulista (Unesp), Botucatu (SP) Departamento de Oftalmologia da Faculdade de Medicina Botucatu da Universidade Estadual Paulista (Unesp), Botucatu (SP) Departamento de Dermatologia e Radioterapia Faculdade de Medicina de Botucatu da Universidade Estadual Paulista (Unesp), Botucatu (SP) Departamento de Bioestatística Instituto Básico Universidade Estadual Paulista (Unesp), Botucatu (SP)
Databáze: OpenAIRE
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