Efeito da peçonha de escorpiões do gênero Tityus sobre a atividade das enzimas do sistema purinérgico em linfócitos e plaquetas de sangue periférico humano
| Autor: | TELMA RODRIGUES DA SILVA |
|---|---|
| Přispěvatelé: | Malson Neilson de Lucena |
| Jazyk: | portugalština |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFMS Universidade Federal de Mato Grosso do Sul (UFMS) instacron:UFMS |
| Popis: | The purinergic system is a signalling system, where the purine nucleotides, ATP (Adenosine 5′-triphosphate) and ADP (Adenosine diphosphate), and the nucleoside, adenosine, act as extracellular messengers. CD39 (ecto-nucleoside triphosphate diphosphohydrolase 1, E-NTPDase1) converts ATP or ADP into AMP, and then CD73 (ecto-5'- nucleotidase, Ecto5'NTase) dephosphorylates AMP into adenosine. CD39 and CD73 regulate the function of several immune cell types, including lymphocytes. Furthermore, there is evidence that changes in CD39 expression and activity affects the potential thrombogenic of a tissue. The objective of this study was to assay the enzymatic activity of CD39 and CD73 in the presence of scorpion venom from Tityus confluens (Tc) and Tityus paraguayensis (Tp) in human lymphocyte and platelet. Our results demonstrate that T.c venom has decreased CD39 activity in ATP hydrolysis in peripheral blood lymphocytes when compared to control (P |
| Databáze: | OpenAIRE |
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