JOURNAL OF NATURAL PRODUCTS
| Autor: | Lima, Flávia Oliveira de, Nonato, Fabiana Regina, Couto, Ricardo David, Barbosa Filho, José Maria, Nunes, Xirley Pereira, Santos, Ricardo Ribeiro dos, Soares, Milena Botelho Pereira, Villarreal, Cristiane Flora |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1021/np100621c |
| Popis: | p. 596-602 Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-03-02T12:23:00Z No. of bitstreams: 1 C__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf: 275086 bytes, checksum: 1b60c6ff0f48421176622c1ede9f1263 (MD5) Made available in DSpace on 2012-03-02T12:23:00Z (GMT). No. of bitstreams: 1 C__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf: 275086 bytes, checksum: 1b60c6ff0f48421176622c1ede9f1263 (MD5) Previous issue date: 2011 7-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models of pain. However, the biochemical events involved in antinociception mediated by 1 are currently not well understood. In the present study, the mechanisms by which 1 exerts its pharmacological actions were investigated. Acute pretreatment of mice with 1 produced a long-lasting antinociceptive effect against complete Freund’s adjuvant (CFA)-induced hyperalgesia. The subchronic administration of 1 inhibited CFA-induced hyperalgesia and paw edema, while it did not cause any apparent toxicity. Another set of experiments showed that 1 inhibited carrageenan-induced mechanical hyperalgesia, but not mechanical hyperalgesia induced by prostaglandin E2 (PGE2), suggesting that it acts upstream of PGE2. Treatment with 1 was able to prevent the plantar tissue neutrophil influx induced by local inflammatory stimuli. In addition, 1 exhibited inhibitory effects on the release of hyperalgesic cytokines (TNF-R and IL-1β) and the production of PGE2, a directly acting hyperalgesic mediator. The present results suggest that the antinociceptive effect of 1 is correlated with the inhibition of neutrophil migration, cytokine release, and PGE2 production and are supportive of the further investigation of the therapeutic potential of 1 to control inflammatory pain. |
| Databáze: | OpenAIRE |
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