Human Immunology
| Autor: | Cunha, Liliane Monteiro, Bittencourt, Paulo Lisboa, Lemos, Clarice P. Abrantes, Moreira, Agnaluce, Almeida, Delvone, Paraná, Raymundo, Andrade, Zilton de Araújo |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1016/j.humimm.2011.10.001 |
| Popis: | Texto completo: acesso restrito. p. 70–74 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-26T13:40:30Z No. of bitstreams: 1 Liliane M. Cunha.pdf: 292661 bytes, checksum: de73f388fe565caa2ab49f08661d281b (MD5) Rejected by Delba Rosa (delba@ufba.br), reason: Por gentileza, certifique-se do endereço eletrôico: http://dx.doi.org/ 10.1016/j.humimm.2011.10.00 on 2014-09-15T16:20:05Z (GMT) Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-09-17T11:58:01Z No. of bitstreams: 1 Liliane M. Cunha.pdf: 292661 bytes, checksum: de73f388fe565caa2ab49f08661d281b (MD5) Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-09-26T15:01:59Z (GMT) No. of bitstreams: 1 Liliane M. Cunha.pdf: 292661 bytes, checksum: de73f388fe565caa2ab49f08661d281b (MD5) Made available in DSpace on 2014-09-26T15:01:59Z (GMT). No. of bitstreams: 1 Liliane M. Cunha.pdf: 292661 bytes, checksum: de73f388fe565caa2ab49f08661d281b (MD5) Previous issue date: 2012-01 Non-organ-specific autoantibodies (NOSA) are well-recognized diagnostic markers of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC), but can also be observed in patients with viral hepatitis as well as in healthy subjects. The aim of this study was to evaluate the prevalence of NOSA in subjects living in a rural community in Brazil and to correlate their occurrence with the presence of liver disease. Seven hundred twenty-five apparently healthy subjects were randomly selected for assessment of antinuclear (ANA), anti-smooth muscle (SMA), antimitochondrial (AMA), anti-liver/kidney microsome type 1, and anti-liver cytosol type 1 antibodies. Subjects with those NOSA were evaluated for the presence of AIH, PBC, and viral hepatitis. Reactivities for all NOSA, SMA, ANA, and AMA were detected, respectively, in 14, 10, 4, and 0.1% of subjects, with a mean titer of 1:40. NOSA-positive subjects were significantly older and more frequently females. No correlation was observed between the occurrence of NOSA and PBC, AIH, or viral hepatitis. The prevalence of NOSA in Brazilians was 14%. They were usually low titer. NOSA were more frequently observed in females and older subjects and their presence was not correlated with the presence of AIH, PBC, or viral hepatitis. |
| Databáze: | OpenAIRE |
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