Journal of the Neurological Sciences
| Autor: | Becker, Jefferson, Callegaro, Dagoberto, Lana-Peixoto, Marco Aurélio, Ferreira, Maria Lúcia B., Melo, Ailton de Souza, Gama, Paulo Diniz da, Souza, Doralina G. B., Teixeira, Carlos A. C., Kaimen-Maciel, Damacio Ramón, Gonçalves, Marcus Vinícius, Matta, André P. C., Abraham, Ronaldo, Furtado, Luís Edmundo T. A., Lino, Angelina, Hauck, Laura, Barreira, Amilton Antunes, Gomes, Irenio |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| Popis: | p. 6–10 Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-10-30T19:34:28Z No. of bitstreams: 1 444444.pdf: 615700 bytes, checksum: fb343d0ce8c37f1b4a108bb5081c14cc (MD5) Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T17:36:47Z (GMT) No. of bitstreams: 1 444444.pdf: 615700 bytes, checksum: fb343d0ce8c37f1b4a108bb5081c14cc (MD5) Made available in DSpace on 2013-10-31T17:36:47Z (GMT). No. of bitstreams: 1 444444.pdf: 615700 bytes, checksum: fb343d0ce8c37f1b4a108bb5081c14cc (MD5) Previous issue date: 2013 Risk factors for development of multiple sclerosis (MS) are still a matter of debate. Latitude gradient, vitamin D deficiency and season of birth are among the most investigated environmental factors associated with the disease. Several international studies suggest that birth in spring is a substantial risk factor for MS. We investigated the season of birth as a potential risk for MS in different geographical regions of Brazil. We conducted a cross-sectional retrospective study with 2257 clinically definite MS patients enrolled in 13 Brazilian MS clinics in the south, southeast, and northeast regions of Brazil. Demographic and clinical data relating to date of birth and clinical features of the disease were collected and analysed, and subsequently compared with birth date among the general Brazilian population. The distribution of date of birth of MS patients showed an increase in spring and a decrease in autumn, with no difference being observed in the other seasons. In conclusion, season of birth is a probable risk factor for MS in most parts of Brazil. These findings may be related to the role that vitamin D plays in MS pathogenesis. Salvador |
| Databáze: | OpenAIRE |
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