Turing patterns inside cells
| Autor: | Strier, D.E., Dawson, S.P. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
cell division
regulatory mechanism chemical model adenosine triphosphate Biophysics morphogenesis animal cell yeast chemistry Models Biological Catalysis Diffusion cell metabolism enzyme kinetics Oscillometry enzyme mechanism steady state diffusion coefficient mathematical computing 6 phosphofructokinase nonhuman adenosine diphosphate theoretical model article methodology glycolysis oscillation Models Theoretical biological model molecular mechanics cell size Models Chemical Phosphofructokinases concentration response protein protein interaction metabolism |
| Zdroj: | PLoS ONE 2007;2(10) Biblioteca Digital (UBA-FCEN) Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales instacron:UBA-FCEN |
| Popis: | Concentration gradients inside cells are involved in key processes such as cell division and morphogenesis. Here we show that a model of the enzymatic step catalized by phosphofructokinase (PFK), a step which is responsible for the appearance of homogeneous oscillations in the glycolytic pathway, displays Turing patterns with an intrinsic length-scale that is smaller than a typical cell size. All the parameter values are fully consistent with classic experiments on glycolytic oscillations and equal diffusion coefficients are assumed for ATP and ADP. We identify the enzyme concentration and the glycolytic flux as the possible regulators of the pattern. To the best of our knowledge, this is the first closed example of Turing pattern formation in a model of a vital step of the cell metabolism, with a built-in mechanism for changing the diffusion length of the reactants, and with parameter values that are compatible with experiments. Turing patterns inside cells could provide a check-point that combines mechanical and biochemical information to trigger events during the cell division process. © 2007 Strier, Ponce Dawson. Fil:Strier, D.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|